Table 3. [Recommended Evaluations Following Initial Diagnosis in Individuals with STAT3 Hyper IgE Syndrome]. - GeneReviews®

System/Concern	Evaluation	Comment
Skin	Dermatologic exam	Newborn rash & eczema during childhood; often improves w/age
Pulmonary	Chest imaging	Detection of bronchiectasis & pneumatoceles
Skeletal	Eval for scoliosis & osteoporosis	Scoliosis typically progresses through adolescence. Osteoporosis can be present in children & adults; DXA screening recommended.
Dental	Dental exam for possible retention of primary teeth
Vascular	Screening for coronary artery & cerebral artery aneurysms	Aneurysms much more common in adults than in children Screening by brain MRA & heart CTA or coronary artery MRA every 3 yrs recommended for adolescents & adults
Other	Consultation w/clinical geneticist &/or genetic counselor

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