| E8.5 | E8.5 | E8.5 | E9.5 | E9.5 | E9.5 | E10.5 | Extraemb. | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene name | ES | E7.5 | Fore | Mid | Hind | Fore | Mid | hind | and + | endoderm | Other tissues | References |
| General endoderm | ||||||||||||
| Sox17 | − | + | ± | + | + | ? | ? | ? | ? | VE | HSCs, endothelia | Kanai-Azuma et al., 2002; MGI |
| Foxa2 | − | + | + | + | + | + | + | + | + | PE,PrE,AVE | notochord, floor plate | Kimura-Yoshida et al., 2007; Ang et al., 1993, emap |
| Claudin6 | ? | + | − | + | + | + | + | + | VE | epiblast, OV, mesonephos | Anderson et al., 2008; Sousa-Nunes et al., 2003; MGI | |
| CXCR4 | − | + | + | + | ± | + | + | − | ± | PE, YS | mesoderm, many after 8.5 | McGrath et al., 1999; Yasunaga et al., 2005; MGI |
| Gata4,6 | ? | + | ± | ± | + | + | + | + | VE,PrE | heart | Hou emap(4); MGI(4) | |
| Tcf2/HNF1b | − | − | ? | + | + | post | + | + | + | VE | notochord | Sherwood et al., 2007; MGI |
| Tmprss2 | − | + | ? | + | + | ? | + | + | + | VE | Prostate | Hou et al., 2007; Moore-Scott et al., 2007; Sherwood et al., 2007; MGI |
| Tacstd1 | ||||||||||||
| (EpCAM) | + | + | + | + | + | + | + | + | + | VE | Ectoderm, lower after 8.5 | Sherwood et al., 2007; MGI |
| Embigin | − | + | + | + | − | ? | ± | ± | − | VE,YS | midbrain, kidney | Huang et al., 1990; Sousa-Nunes et al., 2003; Fan et al., 1998; MGI |
| Hhex | − | + | + | − | − | + | − | − | + | PrE,PE,AVE | endothelia | Sherwood et al., 2007; MGI |
| Cer1 | ? | + | + | − | − | − | − | − | − | AVE | mesoderm | Sherwood et al., 2007; MGI |
| Dkk1 | ? | + | + | − | − | + | − | − | ? | AVE | head mesoderm | Sherwood et al., 2007; MGI |
| AnxA4 | + | ? | − | + | + | − | + | + | ? | VE | Notochord | Sherwood et al., 2007; MGI |
| Bnip1 | + | ? | ± | ± | ± | − | + | + | ? | VE | OV | Sherwood et al., 2007; MGI |
| Cacna1b | − | + | + | + | ? | VE | heart | Sherwood et al., 2007; MGI | ||||
| Clic6 | − | ? | ? | + | + | ± | + | + | + | VE | head mesenchyme | Sherwood et al., 2007; Hou et al., 2007, emap; MGI |
| Dsg2 | + | + | + | + | ? | VE | mesoderm | Sherwood et al., 2007; MGI | ||||
| Krt7 | − | + | + | + | ? | VE, YS | ? | Sherwood et al., 2007; MGI | ||||
| Npnt | − | ? | ? | ? | ? | ? | + | + | ? | VE++ | branchial arch 1 | Sherwood et al., 2007; MGI |
| Rab15 | − | ? | ? | ? | ? | ? | ± | ± | ? | VE++ | OV | Sherwood et al., 2007; MGI |
| Rbm35a | + | ± | ± | ± | ? | + | ± | ± | ? | ? | OV | Sherwood et al., 2007; MGI |
| Ripk4 | − | ± | ± | ? | + | + | + | + | ? | VE | OV | Sherwood et al., 2007; MGI |
| Sh3gl2 | + | ± | + | + | ? | VE | ? | Sherwood et al., 2007; MGI | ||||
| St14 | + | ± | ± | − | + | + | ? | VE | branchial arch 1 | Sherwood et al., 2007; MGI | ||
| Spink3 | − | ± | ± | ± | ± | ? | ? | ? | ? | YS | ectoderm | Sherwood et al., 2007; Hou et al., 2007; MGI |
| Alpha Fetoprotein | − | − | + | + | + | liver | − | − | + | VE,YS | − | Dziadek and Adamson, 1978; MGI |
| Enriched definitive endoderm | ||||||||||||
| Foxa3 | − | ± | + | + | ± | + | + | + | − | germ cells | Ang et al., 1993; Monaghan et al., 1993; MGI | |
| Foxa1 | − | + | ± | + | + | ± | + | + | + | − | forebrain | Monaghan et al., 1993, emap, MGI |
| PYY | ? | − | + | − | − | + | − | − | + | − | brain | Hou et al., 2007; MGI |
| 5730521E12Rik/Nephrocan | − | + | − | + | + | − | + | − | + | − | kidney | Hou et al., 2007; Sherwood et al., 2007; MGI |
| NM_029639 | ? | + | − | − | + | + | + | + | + | − | Oral ectoderm | Moore-Scott et al., 2007 |
| Klf5 | ? | + | − | + | + | − | + | + | + | − | Otic vesicle, somites, brain | Moore-Scott et al., 2007; MGI |
| Epha2 | ? | + | + | − | + | − | − | + | + | − | limb | Moore-Scott et al., 2007; MGI |
| Cdx 2 | ? | + | − | − | + | − | − | + | + | − | Trophectoderm NT, notochord | Hou et al., 2007, emap; MGI |
| Enriched in extraembryonic endoderm | ||||||||||||
| Ceacam1 | + | − | − | − | − | − | − | − | − | VE++ (8.25) | ? | Sherwood et al., 2007; MGI |
| Dpp4 | − | − | − | ++ | − | − | ++ | − | ? | VE++ (8.25) | Somites+/− | Sherwood et al., 2007; MGI |
| Icam | + | − | − | − | − | − | − | − | − | VE++ (8.25) | ? | Sherwood et al., 2007; MGI |
| CD38 | + | − | − | − | − | − | − | − | − | VE++ (8.25) | ? | Sherwood et al., 2007 |
| Timd2 | + | − | − | − | − | − | − | − | − | VE++ (8.25) | ? | Sherwood et al., 2007; MGI |
| DBA lectin | ± | − | − | − | − | − | − | − | − | VE (8.25) | ? | Sherwood et al., 2007 |
| SSEA-4 | − | − | − | − | − | − | − | − | − | VE (8.25) | ? | Sherwood et al., 2007 |
| Claudin9,habp2,spp2,ttr | ? | ? | ± | ± | ± | ? | ? | ? | ? | YS | ? | Hou et al., 2007 |
| Amn | − | − | − | − | − | ? | ? | ? | ? | PrE,VE | ? | Sherwood et al., 2007; Kalantry et al., 2001; MGI |
| HNF4alpha | − | − | − | − | − | − | − | − | liver | VE,YS | Sherwood et al., 2007; Vincent and Robertson, 2004; MGI | |
| Cited1 | ? | − | − | − | − | − | − | − | − | VE | Heart, lateral mesoderm | Rodriguez et al., 2004; Sherwood et al., 2007, emap; MGI |
| Sox7 | ? | − | − | − | − | − | − | − | − | VE | endothelia | Kanai-Azuma et al., 2002; MGI |
| Tdh | ? | − | ? | ? | ? | ? | ? | ? | ? | YS | ? | Hou et al., 2007; MGI |
| Lgals1 | ? | − | ? | ? | ? | ? | ? | ? | ? | YS | ? | Hou et al., 2007; MGI |
| Cubn | ? | − | ? | ? | ? | ? | ? | ? | ? | YS | ? | Hou et al., 2007; MGI |
| Pla2g12b | ? | − | ? | ? | ? | ? | ? | ? | ? | YS | ? | Hou et al., 2007; MGI |
| Apoc2 | ? | − | ? | ? | ? | ? | ? | ? | ? | YS | ? | Hou et al., 2007; MGI |
| Slc39a8 | ? | − | + | + | + | ± | ± | ± | ? | VE | endothelia | Moore-Scott et al., 2007; Sousa-Nunes et al., 2003; MGI |
| Angiomotin | ? | + | ? | ? | ? | ? | ? | ? | ? | VE | ? | Moore-Scott et al., 2007; Shimono and Behringer, 2003; MGI |
| Dp1l1/Reep6 | ? | − | ? | ? | ? | − | − | + | + | VE | brain | Moore-Scott et al., 2007; MGI |
(Emap) Edinburgh mouse Atlas Project, (MGI) mouse genome Informatics. In addition to the references herein, markers in Zebrafish may be found in Brown et al. 2008.
From: Endoderm specification
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