Table 85Evidence profile

Quality assessmentSummary of findings
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsOral PUVANo treatmentRelative (95% CI)Absolute
Clearance (follow-up 7.5–12 weeks)
2
Murray 1980
Rosen 1987
randomised trialsseriousano serious inconsistencyno serious indirectnessno serious imprecisionnone15/34 (44.1%)0/34 (0%)RR 16 (2.23 to 114.89)440 more per 1000 (from 270 more to 620 more)4⊕⊕⊕○
MODERATE
Improved (follow-up 7.5–12 weeks)
2
Murray 1980
Rosen 1987
randomised trialsseriousano serious inconsistencyno serious indirectnessno serious imprecisionnone32/34 (94.1%)17/34 (50%)RR 1.86 (1.32 to 2.6)430 more per 1000 (from 160 more to 800 more)⊕⊕⊕○
MODERATE
Withdrawal due to toxicity (follow-up 7.5–12 weeks)
2
Murray 1980
Rosen 1987
randomised trialsseriousano serious inconsistencyno serious indirectnessvery seriousbnone1/35 (2.9%)0/34 (0%)RR 2.79 (0.12 to 62.48)30 more per 1000 (from 60 fewer to 120 more)d⊕○○○
VERY LOW
Burn (follow-up 7.5–12 weeks)
2
Murray 1980
Rosen 1987
randomised trialsseriousano serious inconsistencyno serious indirectnessseriouscnone5/34 (14.7%)0/34 (0%)RR 6 (0.77 to 46.79)150 more per 1000 (from 10 fewer to 280 more) d⊕⊕○○
LOW
a

2/2 studies had unclear blinding of assessor (allocation concealment was also unclear but disease was bilaterally symmetrical)

b

Confidence interval crosses the boundary for clinical significance in favour of both treatments, as well as line of no effect

c

Confidence interval ranges from a clinically important effect to no effect

d

Calculated from risk difference

From: 9, Phototherapy

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Psoriasis: Assessment and Management of Psoriasis.
NICE Clinical Guidelines, No. 153.
National Clinical Guideline Centre (UK).
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