Table 159Serial PIIINP versus routine liver biopsy – Economic study characteristics

StudyLimitationsApplicabilityOther comments
Chalmers 2005Very serious limitations (g)Partially applicable (h)
  • Cost analysis conducted alongside a multicentre prospective audit in UK and Ireland
  • Costs included biopsy, overnight hospital stay, histology, PIIINP analysis
g

Given that treatment with methotrexate may continue for more than 2 years, time horizon may be insufficient. Does not report incidence of adverse events/complications associated with liver biopsy and any effect on costs. Within trial analysis and so does not incorporate all available evidence on differences between monitoring methods but results appear consistent with results of clinical review.

h

QALYs not used (cost consequence analysis).

From: 12, Methotrexate and monitoring for hepatotoxicity

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Psoriasis: Assessment and Management of Psoriasis.
NICE Clinical Guidelines, No. 153.
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