Table 160Serial PIIINP versus routine liver biopsy – Economic summary of findings

StudyIncremental costIncremental effectsICERUncertainty
Chalmers 2005£25 (a)Fewer liver biopsies per patient per year; fewer normal biopsiesPIIINP is more costly, but reduces number of biopsies (normal and abnormal) performedWhether serial PIIINP with selective liver biopsy was more or less costly than routine liver biopsy was dependent on the unit cost of liver biopsy
Chalmers 2005−£49 (b)PIIINP is less costly and reduces number of biopsies (normal and abnormal) performed
a

Where PIIINP measurement costs £22.50 and liver biopsy costs £270.00 (Essex)

b

Where PIIINP measurement costs £22.50 and liver biopsy costs £577.00 (Manchester)

From: 12, Methotrexate and monitoring for hepatotoxicity

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Psoriasis: Assessment and Management of Psoriasis.
NICE Clinical Guidelines, No. 153.
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