Quality assessmentNo of patientsEffectQuality
No of studiesDesignRisk of biasInconsistencyIndirectnessImprecisionOther considerationsCombined betamethasone dipropionate and calcipotriol
Time-to-absent/very mild disease (follow-up 1 week)
1
Jemec2011 (pooled data from Jemec2008 & van de Kerkhof 2009)
observational studiesano serious risk of biasbno serious inconsistencyno serious indirectnessno serious imprecisionnone1108Patients achieving absent or very mild disease

Week 1: 331 (30.6%)
⊕⊕○○
LOW
Time-to-absent/very mild disease (follow-up 2–8 weeks)
1
Jemec 2008
observational studiesano serious risk of biascno serious inconsistencyno serious indirectnessno serious imprecisionnone541Patients achieving absent or very mild disease

Week 2: 311 (57.5%)

Week 4: 362 (66.9%)

Week 8: 385 (71.2%)
⊕⊕○○
LOW
Time-to-absent/very mild disease (follow-up 2–8 weeks)
1
van de Kerhof2009
observational studiesano serious risk of biasbno serious inconsistencyno serious indirectnessno serious imprecisionnone567Patients achieving absent or very mild disease

Week 2: 278 (49.0%)

Week 4: 311 (54.9%)

Week 8: 388 (68.4%)
⊕⊕○○
LOW
Time-to-absent/very mild disease (follow-up 2–8 weeks)
1
Kragballe 2009
observational studiesano serious risk of biasbno serious inconsistencyno serious indirectnessno serious imprecisionnone207Patients achieving absent or very mild disease

Week 2: 125 (60.4%)

Week 4: 114 (55.1%)

Week 8: 142 (68.6%)
⊕⊕○○
LOW
a

Although the data are taken from randomised trials the benefit of control data is not being utilised as considerations are being made based on single interventions without reference to the comparator arm

b

Unclear allocation concealment may have biased patient selection for this intervention

c

Unclear allocation concealment may have biased patient selection for this intervention and there was a high rate of dropout (21.0%)

From: 8, Topical therapy

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Psoriasis: Assessment and Management of Psoriasis.
NICE Clinical Guidelines, No. 153.
National Clinical Guideline Centre (UK).
Copyright © National Clinical Guideline Centre - October 2012.

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