Quality assessmentNo of patientsEffectQuality
No of studiesDesignRisk of biasInconsistencyIndirectnessImprecisionOther considerationsTacrolimus BD
Mean time to maximum response (PGA) (follow-up 57 days)
1
Lebwohl 2004
observational studiesano serious risk of biasbno serious inconsistencyno serious indirectnessno serious imprecisionnoneTacrolimus 0.1%

112
Patients achieving excellent improvement or clearing

Day 8: 24.8%

Day 57: 66.7%
⊕⊕○○
LOW
Mean time to maximum response (PGA) (follow-up 57 days)
1
Lebwohl 2004
observational studiesano serious risk of biasbno serious inconsistencyno serious indirectnessvery seriouscnoneTacrolimus 0.1%

112
Based on graphical representation of the % with excellent improvement or clearing the majority of those who achieved success did so by day 29, with a small decrease in % to day 43 but a further increase of <5% between days 29 and 57⊕○○○
VERY LOW
Mean time to maximum response (PGA) (follow-up 6 weeks)
1
Liao 2007
observational studiesano serious risk of biasbno serious inconsistencyseriousdvery seriouscnoneTacrolimus 0.03%

25
Graphical representation of % clear or nearly clear over time demonstrated that maximum effect was reached not reached by week 6⊕○○○
VERY LOW
a

Although the data are taken from randomised trials the benefit of control data is not being utilised as considerations are being made based on single interventions without reference to the comparator arm

b

Unclear allocation concealment may have biased patient selection for this intervention

c

Interpreted from graphical representation

d

Incorrect outcome measure

From: 8, Topical therapy

Cover of Psoriasis
Psoriasis: Assessment and Management of Psoriasis.
NICE Clinical Guidelines, No. 153.
National Clinical Guideline Centre (UK).
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