Quality assessmentNo of patientsEffectQuality
No of studiesDesignRisk of biasInconsistencyIndirectnessImprecisionOther considerationsPimecrolimus 1% BD
Time-to-clear/nearly clear (follow-up 8 weeks)
1
Gribetz 2004
observational studies1no serious risk of bias2no serious inconsistencyno serious indirectnessno serious imprecisionnone28Percentage of patients clear or almost clear

Baseline: 0%

Day 3: 14.3%

Day 7: 35.7%

Week 2: 53.6%

Week 4: 64.3%

Week 6: 67.9%

Week 8: 71.4%
⊕⊕○○
LOW
a

Although the data are taken from randomised trials the benefit of control data is not being utilised as considerations are being made based on single interventions without reference to the comparator arm

b

Unclear allocation concealment may have biased patient selection for this intervention

From: 8, Topical therapy

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Psoriasis: Assessment and Management of Psoriasis.
NICE Clinical Guidelines, No. 153.
National Clinical Guideline Centre (UK).
Copyright © National Clinical Guideline Centre - October 2012.

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