Evidence Table 10. Randomized controlled trials comparing antibiotic treatment for acute bacterial rhinosinusitis

Treatment ComparisonsNumber of StudiesStudy(s)
Amoxicillin vs. ...
Amoxicillin-clavulanate1 Wald, Chiponis, and Ledesma-Medina, 1986
Amoxicillin1 Kment, Georgopoulos, Ridl et al., 1995
Azidocillin1 Axelsson, Jensen, Melin et al., 1981
Azithromycin2 Casiano, 1991
Felstead and Daniel, 1991
Bacampicillin1 Nord, 1988
Brodimoprim1 Nyffenegger, Riebenfeld, and Macciocchi, 1991
Cefaclor2 Wald, Reilly, Casselbrant et al., 1984
Huck, Reed, Nielsen et al., 1993
Cefixime4 Fiscella and Chow, 1991
Edelstein, Avner, Chow et al., 1993
Matthews and Suprax/Amoxicillin Clinical Study Team, 1997
Rimmer and Suprax/Amoxicillin Clinical Study Team, 1997
Cefpodoxime1 von Sydow, Savolainen, and Soderqvist, 1995
Cefuroxime 1 Brodie, Knight, and Cunningham, 1989
Clarithromycin2 Karma, Pukander, Penttila et al., 1991
Calhoun and Hokanson, 1993
Cyclacillin1 Scheld, Sydnor, Farr et al., 1986
Minocycline1 Mattucci, Levin, and Habib, 1986
Penicillin1 Lindbaek, Hjortdahl, and Johnsen, 1996a
Pivampicillin4 Axelsson, Jensen, Melin et al., 1981
Moran, 1983
1 Shenderey, Marsh, and Talbot, 1985
1 Moorhouse, Hickey, and O'Hanrahan, 1985
Placebo3 Wald, Chiponis, and Ledesma-Medina, 1986
Lindbaek, Hjortdahl, and Johnsen, 1996a
van Buchem, Knottnerus, Schrijnemaekers et al., 1997
Amoxicillin-clavulanate vs. ...
Cefpodoxime1 Camacho, Cobo, Otte et al., 1992
Ceftibuten1 De Abate, Perrotta, and Dennington, 1992
Clarithromycin1 Dubois, Saint-Pierre, and Tremblay, 1993
Loracarbef1 Sydnor, Scheld, Gwaltney et al., 1992
Placebo1 Wald, Chiponis, and Ledesma-Medina, 1986
Ampicillin vs. ...
Doxycycline1 Agbim, 1974
Azithromycin vs. ...
Azithromycin1 Ficnar, Huzjak, Oreskovic et al., 1997
Cefaclor1 O'Doherty, 1996
Clarithromycin1 Muller, 1993
Erythromycin1 Felstead and Daniel, 1991
Penicillin1 Haye, Lingaas, Hoivik et al., 1996
Roxithromycin1 Muller, 1996
Bacampicillin vs. ...
Bacampicillin2 Sorri, Peltomaki, and Jokinen, 1981
von Sydow, Einarsson, Grafford et al., 1981
Brodimoprim vs. ...
Cephalexin1 Bockmeyer, Riebenfeld, and Clasen, 1994
Doxycycline4 Salmi, Lehtomaki, and Kylmamaa, 1986
Arndt, Riebenfeld, Maier et al., 1994
Rahlfs, Macciocchi, and Monti, 1996 2
Roxithromycin1 Manzini and Caroggio, 1993
Cefaclor vs. ...
Cefuroxime1 Sydnor, Gwaltney, Cocchetto et al., 1989
Cefixime1 Carenfelt, Melen, Odkvist et al., 1990
Cefpodoxime1 Gehanno, Depondt, Barry et al., 1990
Cefetamet1 Gauger, Inoka, Germano et al., 1990
Cefprozil vs. ...
Amoxicillin-clavulanate1 Russell, Nolen, Allen et al. 1997
(3 arms/2 dosages)
Cefprozil1 Russell, Nolen, Allen et al., 1997
Cefuroxime vs. ...
Sparfloxacin1 Gehanno and Berche, 1996
Clarithromycin vs. ...
Roxithromycin1 de Campora, Camaioni, Leonardi et al., 1992
Cyclacillin vs. ...
Placebo1 Ganança and Trabulsi, 1973
Doxycycline vs. ...
Loracarbef1 Scandinavian Study Group, 1993
Placebo1 Stalman, van Essen, van der Graaf et al., 1997
Spiramycin1 Boezeman, Kayser, and Siemelink, 1988
Erythromycin vs. ...
Erythromycin1 Wuolijoki, Flygare, Hilden et al., 1988
(3 arms/3 dosages)
Lincomycin vs. ...
Irrigation1 Axelsson, Chidekel, Grebelius et al., 1970
Loracarbef vs. ...
Loracarbef1 Zeckel, Johns, Masica et al., 1995
Methacycline vs. ...
Placebo1 Axelsson, Chidekel, Grebelius et al., 1971
Penicillin vs. ...
Erythromycin2 von Sydow, Axelsson, and Jensen, 1984
Soderstrom, Blomberg, Christensen et al., 1991
Irrigation1 Axelsson, Chidekel, Grebelius et al., 1970
Lincomycin1 Axelsson, Chidekel, Grebelius et al., 1970
Methacycline1 Axelsson, Chidekel, Grebelius et al., 1971
Placebo2 Axelsson, Chidekel, Grebelius et al., 1971
Wald, Chiponis, and Ledesma-Medina, 1986
TMP/SMZ1 Quick, 1975
Pivampicillin vs. ...
Azidocillin1 Axelsson, Jensen, Melin et al., 1981
Placebo1 Jeppesen and Illum, 1972
Pivampicillin1 Christensen and Hartmann, 1980
Tetracycline vs. ...
Clindamycin1 Westerman, Panzer, and Atkinson, 1975
TMP/SMZ1 Otte, Viada, Buchi et al., 1983
Pivampicillin 1 1 Beatson, Marsh, and Talbot, 1985
vs. 3
Trimethoprim/
Sulfamethoxazole (TMP/SMZ) vs. ...
Erythromycin1 Federspil and Koch, 1983
Pivampicillin 1 2 Osman and Menday, 1983
Wallace, Marsh, and Talbot, 1985
Sulphadiazine/TMP1 Federspil and Bamberg, 1981
TMP/SMZ1 Williams, Holleman, Samsa et al., 1995

From: Evidence Tables

Cover of Diagnosis and Treatment of Acute Bacterial Rhinosinusitis
Diagnosis and Treatment of Acute Bacterial Rhinosinusitis.
Evidence Reports/Technology Assessments, No. 9.
Lau J, Zucker D, Engels EA, et al.

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