| Author, Year Identifier 2 | Results 3 : Percentage Cure or Improved (number / total) | Discontinuation Due To Major Adverse Events (no. of events) | Minor Adverse Events (no. of events) | Additional Comments / Data |
|---|---|---|---|---|
|
Axelsson 1970 70286389 |
Penicillin V:82.8%
(29/35) Lincomycin: 84.6% (33/39) | None |
Penicillin V: nausea (2), stool
(1) Lincomycin: loose bowel movement (27) | At day 5 and day 10, all arms showed radiograph improvement. |
|
von Sydow 1984 85114999 |
Erythromycin:97.9%
(46/47) Penicillin V:90.9% (40/44) |
Erythromycin: epigastric pain &
vomiting(1) Penicillin V: urticaria (1) | Mostly GI-related Erythromycin: (18), some epigastric pain Penicillin V: (9) | |
|
Lindbaek 1996a 96343743 |
Amoxicillin: 88.6%
(39/44) Penicillin V: 82.1% (32/39) | 12 patients discontinued tx; 3 had severe GI events & withdrew, 6 placebo cases were given amoxicillin & 1 was given penicillin V. 2 amoxicillin cases were given doxycycline. | More than half in tx had adverse events, mainly diarrhea. | Mean duration of sinusitis: Amoxicillin: 9 days Penicillin: 11 days Placebo: 17 days Mean(95% CI) reduction of clinical severity scores: Amoxicillin: 5.5 (4.9, 6.0) Penicillin V: 5.4 (5.0, 5.8) Placebo: 3.4 (2.8, 4.0 |
|
Haye 1996 97151573 | Outcome at 10-12 days Azithromycin: 97.3% (214/220) Penicillin V: 94.9% (205/216) | None | Mostly GI-related (diarrhea, nausea, abdominal pain), some
skin-related, & loss of appetite
- Azithromycin: (89) Penicillin V: (112) |
Except folate inhibitors.
MEDLINE or unique identifying number assigned by EPC. Only first author cited.
Clinical or global evaluation.
Abbreviations: GI - gastrointestinal; tx - treatment; CI - confidence interval.
From: Evidence Tables
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