Table 11.1.1, Results of Mixed Treatment Comparison Analysis - Neutropenic Sepsis: Prevention and Management of Neutropenic Sepsis in Cancer Patients

		Mortality		Infectious Deaths	Clinical failure
3	uridipenicillin vs carbapenem	0.57	0.38 to 0.88	0.94	0.55 to 1.57	1.13	0.9 to 1.43
9	3rdGenCephalosporin vs carbapenem	0.84	0.62 to 1.19	1.03	0.68 to 1.65	1.03	0.86 to 1.22
5	4thGenCephalosporin vs carbapenem	1.18	0.81 to 1.66	1.16	0.64 to 2.22	0.97	0.78 to 1.23
4	uridipenicillin+aminoglycoside vs carbapenem	1.03	0.77 to 1.4	1.87	1.04 to 3.82	1.1	0.87 to 1.39
10	3rdGenCephalosporin+aminoglycoside vs carbapenem	1.07	0.75 to 1.54	1.31	0.8 to 2.06	1.19	0.99 to 1.44
	4thGenCephalosporin+aminoglycoside vs carbapenem	1.27	0.54 to 2.59	1.71	0.15 to 6.08	0.9	0.55 to 1.47
1	3rdGenCephalosporin vs uridipenicillin	1.5	0.91 to 2.26	1.11	0.72 to 1.73	0.91	0.72 to 1.14
3	4thGenCephalosporin vs uridipenicillin	2.06	1.28 to 3.11	1.25	0.68 to 2.15	0.86	0.68 to 1.11
2	uridipenicillin+aminoglycoside vs uridipenicillin	1.83	1.2 to 2.7	1.98	1.1 to 3.84	0.97	0.74 to 1.27
3	3rdGenCephalosporin+aminoglycoside vs uridipenicillin	1.87	1.13 to 2.97	1.4	0.74 to 2.54	1.06	0.83 to 1.37
	4thGenCephalosporin+aminoglycoside vs uridipenicillin	2.21	0.81 to 4.93	1.8	0.2 to 6.97	0.8	0.49 to 1.32
7	4thGenCephalosporin vs 3rdGenCephalosporin	1.4	0.93 to 1.96	1.12	0.64 to 2.05	0.95	0.77 to 1.19
5	uridipenicillin+aminoglycoside vs 3rdGenCephalosporin	1.22	0.9 to 1.69	1.8	1.03 to 3.6	1.06	0.86 to 1.34
7	3rdGenCephalosporin+aminoglycoside vs 3rdGenCephalosporin	1.25	0.89 to 1.86	1.26	0.76 to 2.11	1.16	0.96 to 1.42
	4thGenCephalosporin+aminoglycoside vs 3rdGenCephalosporin	1.48	0.62 to 3.16	1.62	0.17 to 6.23	0.87	0.54 to 1.44
	uridipenicillin+aminoglycoside vs 4thGenCephalosporin	0.88	0.59 to 1.34	1.61	0.72 to 3.61	1.12	0.86 to 1.49
2	3rdGenCephalosporin+aminoglycoside vs 4thGenCephalosporin	0.89	0.61 to 1.46	1.09	0.58 to 2.29	1.23	0.95 to 1.58
2	4thGenCephalosporin+aminoglycoside vs 4thGenCephalosporin	1.08	0.48 to 2.13	1.47	0.17 to 5.34	0.92	0.58 to 1.48
	3rdGenCephalosporin+aminoglycoside vs uridipenicillin+aminoglycoside	1.02	0.7 to 1.53	0.69	0.28 to 1.43	1.09	0.83 to 1.44
	4thGenCephalosporin+aminoglycoside vs uridipenicillin+aminoglycoside	1.2	0.49 to 2.54	0.9	0.11 to 3.55	0.82	0.49 to 1.36
	4thGenCephalosporin+aminoglycoside vs 3rdGenCephalosporin+aminoglycoside	1.18	0.47 to 2.51	1.39	0.16 to 5.19	0.75	0.45 to 1.26

Mortality

Infectious Deaths

Clinical failure

n Trials

Comparators

Indirect OR

95% CrI

Indirect OR

95% CrI

Indirect OR

95% CrI

uridipenicillin vs carbapenem

0.57

0.38 to 0.88

0.94

0.55 to 1.57

1.13

0.9 to 1.43

3rdGenCephalosporin vs carbapenem

0.84

0.62 to 1.19

1.03

0.68 to 1.65

1.03

0.86 to 1.22

4thGenCephalosporin vs carbapenem

1.18

0.81 to 1.66

1.16

0.64 to 2.22

0.97

0.78 to 1.23

uridipenicillin+aminoglycoside vs carbapenem

1.03

0.77 to 1.4

1.87

1.04 to 3.82

1.1

0.87 to 1.39

3rdGenCephalosporin+aminoglycoside vs carbapenem

1.07

0.75 to 1.54

1.31

0.8 to 2.06

1.19

0.99 to 1.44

4thGenCephalosporin+aminoglycoside vs carbapenem

1.27

0.54 to 2.59

1.71

0.15 to 6.08

0.9

0.55 to 1.47

3rdGenCephalosporin vs uridipenicillin

1.5

0.91 to 2.26

1.11

0.72 to 1.73

0.91

0.72 to 1.14

4thGenCephalosporin vs uridipenicillin

2.06

1.28 to 3.11

1.25

0.68 to 2.15

0.86

0.68 to 1.11

uridipenicillin+aminoglycoside vs uridipenicillin

1.83

1.2 to 2.7

1.98

1.1 to 3.84

0.97

0.74 to 1.27

3rdGenCephalosporin+aminoglycoside vs uridipenicillin

1.87

1.13 to 2.97

1.4

0.74 to 2.54

1.06

0.83 to 1.37

4thGenCephalosporin+aminoglycoside vs uridipenicillin

2.21

0.81 to 4.93

1.8

0.2 to 6.97

0.8

0.49 to 1.32

4thGenCephalosporin vs 3rdGenCephalosporin

1.4

0.93 to 1.96

1.12

0.64 to 2.05

0.95

0.77 to 1.19

uridipenicillin+aminoglycoside vs 3rdGenCephalosporin

1.22

0.9 to 1.69

1.8

1.03 to 3.6

1.06

0.86 to 1.34

3rdGenCephalosporin+aminoglycoside vs 3rdGenCephalosporin

1.25

0.89 to 1.86

1.26

0.76 to 2.11

1.16

0.96 to 1.42

4thGenCephalosporin+aminoglycoside vs 3rdGenCephalosporin

1.48

0.62 to 3.16

1.62

0.17 to 6.23

0.87

0.54 to 1.44

uridipenicillin+aminoglycoside vs 4thGenCephalosporin

0.88

0.59 to 1.34

1.61

0.72 to 3.61

1.12

0.86 to 1.49

3rdGenCephalosporin+aminoglycoside vs 4thGenCephalosporin

0.89

0.61 to 1.46

1.09

0.58 to 2.29

1.23

0.95 to 1.58

4thGenCephalosporin+aminoglycoside vs 4thGenCephalosporin

1.08

0.48 to 2.13

1.47

0.17 to 5.34

0.92

0.58 to 1.48

3rdGenCephalosporin+aminoglycoside vs uridipenicillin+aminoglycoside

1.02

0.7 to 1.53

0.69

0.28 to 1.43

1.09

0.83 to 1.44

4thGenCephalosporin+aminoglycoside vs uridipenicillin+aminoglycoside

1.2

0.49 to 2.54

0.9

0.11 to 3.55

0.82

0.49 to 1.36

4thGenCephalosporin+aminoglycoside vs 3rdGenCephalosporin+aminoglycoside

1.18

0.47 to 2.51

1.39

0.16 to 5.19

0.75

0.45 to 1.26

From: Initial Treatment: guideline chapter six

Neutropenic Sepsis: Prevention and Management of Neutropenic Sepsis in Cancer Patients.

NICE Clinical Guidelines, No. 151.

National Collaborating Centre for Cancer (UK).

London: National Institute for Health and Clinical Excellence (NICE); 2012 Sep.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Table 11.1.1Results of Mixed Treatment Comparison Analysis