Table 11.1.2, Comparison of pair wise and MTC analyses for mortality - Neutropenic Sepsis: Prevention and Management of Neutropenic Sepsis in Cancer Patients

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Table 11.1.2Comparison of pair wise and MTC analyses for mortality

n Trials	Comparators	Direct OR	95% CI	Indirect OR	95% CrI
3	uridipenicillin vs carbapenem	0.4	0.115 to 1.388	0.57	0.38 to 0.88
9	3rdGenCephalosporin vs carbapenem	0.997	0.597 to 1.664	0.84	0.62 to 1.19
5	4thGenCephalosporin vs carbapenem	1.368	0.714 to 2.624	1.18	0.81 to 1.66
4	uridipenicillin+aminoglycoside vs carbapenem	1.004	0.565 to 1.786	1.03	0.77 to 1.4
10	3rdGenCephalosporin+aminoglycoside vs carbapenem	1.065	0.691 to 1.641	1.07	0.75 to 1.54
	4thGenCephalosporin+aminoglycoside vs carbapenem	NA	NA	1.27	0.54 to 2.59
1	3rdGenCephalosporin vs uridipenicillin	1.178	0.072 to 19.167	1.5	0.91 to 2.26
3	4thGenCephalosporin vs uridipenicillin	1.56	0.73 to 3.33	2.06	1.28 to 3.11
2	uridipenicillin+aminoglycoside vs uridipenicillin	1.488	0.859 to 2.576	1.83	1.2 to 2.7
3	3rdGenCephalosporin+aminoglycoside vs uridipenicillin	2.155	0.871 to 5.333	1.87	1.13 to 2.97
	4thGenCephalosporin+aminoglycoside vs uridipenicillin	NA	NA	2.21	0.81 to 4.93
7	4thGenCephalosporin vs 3rdGenCephalosporin	1.558	0.937 to 2.589	1.4	0.93 to 1.96
5	uridipenicillin+aminoglycoside vs 3rdGenCephalosporin	1.247	0.903 to 1.722	1.22	0.9 to 1.69
7	3rdGenCephalosporin+aminoglycoside vs 3rdGenCephalosporin	1.204	0.685 to 2.118	1.25	0.89 to 1.86
	4thGenCephalosporin+aminoglycoside vs 3rdGenCephalosporin	NA	NA	1.48	0.62 to 3.16
	uridipenicillin+aminoglycoside vs 4thGenCephalosporin	NA	NA	0.88	0.59 to 1.34
2	3rdGenCephalosporin+aminoglycoside vs 4thGenCephalosporin	0.593	0.07 to 4.996	0.89	0.61 to 1.46
2	4thGenCephalosporin+aminoglycoside vs 4thGenCephalosporin	1.696	0.154 to 18.673	1.08	0.48 to 2.13
	3rdGenCephalosporin+aminoglycoside vs uridipenicillin+aminoglycoside	NA	NA	1.02	0.7 to 1.53
	4thGenCephalosporin+aminoglycoside vs uridipenicillin+aminoglycoside	NA	NA	1.2	0.49 to 2.54
	4thGenCephalosporin+aminoglycoside vs 3rdGenCephalosporin+aminoglycoside	NA	NA	1.18	0.47 to 2.51

From: Initial Treatment: guideline chapter six

Neutropenic Sepsis: Prevention and Management of Neutropenic Sepsis in Cancer Patients.

NICE Clinical Guidelines, No. 151.

National Collaborating Centre for Cancer (UK).

London: National Institute for Health and Clinical Excellence (NICE); 2012 Sep.

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