| Outcome | Trials (episodes) | Risk ratio (95% CI; P value) |
|---|---|---|
| Inpatient versus Outpatient | ||
| Failure (PPA) | 6 (738) | 0.81 (0.55–1.19; 0.28) |
| Adults | 4 (470) | 0.79 (0.52–1.20; 0.27) |
| Children | 2 (268) | 0.93 (0.32–2.71; 0.89) |
| Mortality | 7 (855) | RR 0.87 (0.30 – 2.57) |
| Toxicity | Data only reported by one study | |
| Readmission | Not applicable to this primary objective | |
| Critical care | No admissions to critical care in any of the included studies | |
| Quality of life | Data only reported by one study | |
| Length of stay | Not a relevant comparison. Only one group considered outpatients | |
| Outpatient IV versus Outpatient oral | ||
| Failure (PPA) | 8 (857) | 0.93 (0.65–1.32; 0.67) |
| Adults | 3 (218) | 0.95 (0.29–3.13; 0.94) |
| Children | 5 (639) | 0.90 (0.64–1.26; 0.53) |
| Mortality | No deaths in any of the included studies | |
| Toxicity | 4 (404) | 0.59 (0.06–5.85; 0.65) |
| Adults | 2 (177) | 0.72 (0.02–33.74; 0.87) |
| Children | 2 (227) | 0.40 (0.02–9.55; 0.57) |
| Readmission | 7 (816) | 0.62 (0.28–1.39; 0.25) |
| Adults | 2 (177) | 0.47 (0.01–14.61; 0.66) |
| Children | 5 (639) | 0.52 (0.24–1.09; 0.08) |
| Critical care | No admissions to critical care in any of the included studies | |
| Quality of life | Data not reported by any of the included studies | |
| Length of stay | Not a relevant comparison in studies considering only outpatients | |
From: Initial Treatment: guideline chapter six
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