From: Childhood Cancer Genomics (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 6. EWS and TLS Fusions and Translocations in Ewing Sarcoma
| TET Family Partner | Fusion With ETS-like Oncogene Partner | Translocation | Comment |
|---|---|---|---|
| EWS | EWSR1-FLI1 | t(11;22)(q24;q12) | Most common; ~85% to 90% of cases |
| EWSR1-ERG | t(21;22)(q22;q12) | Second most common; ~10% of cases | |
| EWSR1-ETV1 | t(7;22)(p22;q12) | Rare | |
| EWSR1-ETV4 | t(17;22)(q12;q12) | Rare | |
| EWSR1-FEV | t(2;22)(q35;q12) | Rare | |
| EWSR1-NFATc2a | t(20;22)(q13;q12) | Rare | |
| EWSR1-POU5F1a | t(6;22)(p21;q12) | ||
| EWSR1-SMARCA5a | t(4;22)(q31;q12) | Rare | |
| EWSR1-ZSGa | t(6;22)(p21;q12) | ||
| EWSR1-SP3a | t(2;22)(q31;q12) | Rare | |
| TLS (also called FUS) | TLS-ERG | t(16;21)(p11;q22) | Rare |
| TLS-FEV | t(2;16)(q35;p11) | Rare |
aThese partners are not members of the ETS family of oncogenes.