From: Childhood Cancer Genomics (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 1. Acute Leukemias of Ambiguous Lineage According to the World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissuesa
| Condition | Definition |
|---|---|
| Acute undifferentiated leukemia | Acute leukemia that does not express any marker considered specific for either lymphoid or myeloid lineage |
| Mixed phenotype acute leukemia with t(9;22)(q34;q11.2); BCR-ABL1 (MPAL with BCR-ABL1) | Acute leukemia meeting the diagnostic criteria for mixed phenotype acute leukemia in which the blasts also have the (9;22) translocation or the BCR-ABL1 rearrangement |
| Mixed phenotype acute leukemia with t(v;11q23); KMT2A (MLL) rearranged (MPAL with KMT2A) | Acute leukemia meeting the diagnostic criteria for mixed phenotype acute leukemia in which the blasts also have a translocation involving the KMT2A gene |
| Mixed phenotype acute leukemia, B/myeloid, NOS (B/M MPAL) | Acute leukemia meeting the diagnostic criteria for assignment to both B and myeloid lineage, in which the blasts lack genetic abnormalities involving BCR-ABL1 or KMT2A |
| Mixed phenotype acute leukemia, T/myeloid, NOS (T/M MPAL) | Acute leukemia meeting the diagnostic criteria for assignment to both T and myeloid lineage, in which the blasts lack genetic abnormalities involving BCR-ABL1 or KMT2A |
| Mixed phenotype acute leukemia, B/myeloid, NOS—rare types | Acute leukemia meeting the diagnostic criteria for assignment to both B and T lineage |
| Other ambiguous lineage leukemias | Natural killer–cell lymphoblastic leukemia/lymphoma |
NOS = not otherwise specified.
aAdapted from Béné MC: Biphenotypic, bilineal, ambiguous or mixed lineage: strange leukemias! Haematologica 94 (7): 891-3, 2009.[156] Obtained from Haematologica/the Hematology Journal website http://www
.haematologica.org.