From: Childhood Cancer Genomics (PDQ®)
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 3. Common Pediatric Acute Myeloid Leukemia (AML) Chromosomal Translocations
| Gene Fusion Product | Chromosomal Translocation | Prevalence in Pediatric AML (%) |
|---|---|---|
| KMT2A (MLL) translocated | 11q23.3 | 25.0 |
| NUP98-NSD1a | t(5;11)(q35.3;p15.5) | 7.0 |
| CBFA2T3-GLIS2a | inv(16)(p13.3;q24.3) | 3.0 |
| NUP98-KDM5A4a | t(11;12)(p15.5;p13.5) | 3.0 |
| DEK-NUP214 | t(6;9)(p23;q34.1) | 1.7 |
| RBM15(OTT)-MKL1(MAL) | t(1;22)(p13.3;q13.1) | 0.8 |
| MNX1-ETV6 | t(7;12)(q36.3;p13.2) | 0.8 |
| KAT6A-CREBBP | t(8;16)(p11.2;p13.3) | 0.5 |
| RUNX1-RUNX1T1 | t(8;21)(q22;q22) | 13–14 |
| CBFB-MYH11 | inv(16)(p13.1;q22) or t(16;16)(p13.1;q22) | 4–9 |
| PML-RARA | t(15;17)(q24;q21) | 6–11 |
aCryptic chromosomal translocation.