Table 4.

Treatment of Manifestations in Individuals with TRIO-Related Neurodevelopmental Disorder

Manifestation/ConcernTreatmentConsiderations/Other
Developmental delay /
Intellectual disability /
Neurobehavioral issues 		See Developmental Delay / Intellectual Disability Management Issues.
Seizures Standard treatment(s) as recommended by neurologist
Feeding issues /
Poor weight gain
  • Feeding therapy
  • Gastrostomy tube placement may be required for persistent feeding issues.
Consider assessment of dietary diary & calorie counts.
GERD &/or constipation Standard treatment(s)
Scoliosis/
Kyphosis 		Standard treatment as recommended by orthopedist
Dental crowding /
Malocclusion 		Standard treatment as recommended by dentist/orthodontist
Cardiovascular Standard treatment as recommended by cardiologist
Recurrent infections Mgmt per immunologist

GERD = gastroesophageal reflux disease

From: TRIO-Related Neurodevelopmental Disorder

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