Table 3b.

Suspected Genetic Risk Factors for Parkinson Disease

GenePD Designation 1MOI% of Adult PDComments
ARSA PARK-ARSAADVery rare
  • Juvenile-, early-, or late-onset PD
  • Tremor-dominant parkinsonism
  • Slow progression
  • Good response to levodopa
  • Mild cognitive impairment
  • Autonomic dysfunction
CHCHD2 PARK-CHCHD2ADVery rare
  • Early or late onset
  • Frequent depression
  • Dementia uncommon
  • Good response to levodopa
  • Persons of Asian descent
LRP10 PARK-LRP10ADVery rare
  • Late-onset PD
  • High prevalence of dementia, which may be a first sign
  • Good response to levodopa
PSAP PARK-PSAPADVery rare
  • Early- or late-onset PD
  • Motor fluctuations
  • Dyskinesia
  • Good response to levodopa
  • Persons of Japanese descent
RIC3 PARK-RIC3ADVery rare
  • Early- or late-onset PD
  • Dystonia
  • Restless legs syndrome
  • REM sleep behavior disorder
  • Psychosis
  • Persons of South Indian descent
TMEM230 2PARK-TMEM230ADVery rare
  • Late-onset PD
  • Slow progression
  • Good response to levodopa

Based on Dulski et al [2022], Dulski et al [unpublished data]

1.

Nomenclature based on Lange et al [2022]

From: VPS35-Related Parkinson Disease

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