Table CHip fracture surgery, intervention class versus class: Summary of “sufficient evidence”

ComparisonOutcome*Design: No. Studies (N)EstimatesConclusionsSoE Grade
LMWH vs. FXaIDVT, totalRCT: 3 (1816)0.55, 2.71, 3.81Favors LMWHModerate

This table presents the pairwise results of comparisons for which there was sufficient evidence. It does not include pairwise results for which the evidence was graded “insufficient” strength of evidence [SoE]). Other abbreviations: DVT = deep vein thrombosis, FXaI = factor Xa inhibitor, LMWH = low molecular weight heparin; RCT = randomized controlled trials.

*

Evaluated outcomes included total venothromboembolism (VTE), symptomatic VTE, total pulmonary embolism (PE), fatal PE, symptomatic PE, total deep vein thrombosis (DVT), symptomatic DVT, proximal DVT, postthrombotic syndrome, pulmonary hypertension, major bleeding (total), surgical site or wound bleeding, other major bleeding (specific), surgical site or wound infection, surgical site or wound complications (other than bleeding or infection), heparin-induced thrombocytopenia, mechanical device complications, inferior vena cava filter complications, and other clinically significant adverse events.

This low estimate (0.55) was highly imprecise and nonsignificant (95% confidence interval 0.05, 5.58). The other two estimates were precise and statistically significant. The imprecision of the low estimate makes it, in fact, consistent with the two other significant estimates.

From: Executive Summary

Cover of Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update
Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update [Internet].
Comparative Effectiveness Reviews, No. 191.
Balk EM, Ellis AG, Di M, et al.

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