Table 1Base case parameters applied in the economic model for all interventions

DescriptionMean (95%CI)Evidence
Utility gain associated with a response to treatment0.071 (0.02 –0.147)Mearin (2004), difference between high and low intensity symptoms
Response rate for no treatment arm45% (33% – 57%)Mearin (2004), 1 month probability of transition from high to low intensity symptoms
Response rate for usual care in people with refractory IBS25% (19% – 32%)Comparator arms of RCTs in psychological interventions*
Discounting rate for costs and benefits3.5%NICE (2007), NICE reference case value
Cost for GP appointment to initiate intervention / review medication£18Netten (2006), GP cost per surgery consultation (excluding qualification and direct care staff costs)
*

Psychological interventions includes CBT, psychotherapy and hypnotherapy

From: 5, Methods used to develop the guideline

Cover of Irritable Bowel Syndrome in Adults
Irritable Bowel Syndrome in Adults: Diagnosis and Management of Irritable Bowel Syndrome in Primary Care [Internet].
NICE Clinical Guidelines, No. 61.
National Collaborating Centre for Nursing and Supportive Care (UK).
Copyright © 2008, Royal College of Nursing.

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