Table 12Mortality, arranged by treatment

Number of studiesNumber of armsTotal NPooled proportion (95% CI)GRADE
Daclatasvir + sofosbuvirTrial evidence
ALLY-224,131,137,220222
Abdel-Aziz 201710
Yakoot 2017223
ALLY-325,111,137,148,149
475350.01 (0.00, 0.01)⊕⊕⊕⊕
All evidence
Iwamoto 201793
Mangia 2016a132
VASCUVALDIC 2173,174
Mehta 2017138
Ji 201698
ALLY-224,131,137,220222
Abdel-Aziz 201710
Yakoot 2017223
ALLY-325,111,137,148,149
ANRS CO22 HEPATHER55,164
Autorisation Temporaire d’Utilisation (ATU) Program120
112221560.01 (0.00, 0.01)⊕⊕⊕⊕
Glecaprevir + pibrentasvirTrial evidence
SURVEYOR-I65,118
SURVEYOR-II65,118
EXPEDITION-15658
345390.01 (0.00, 0.02)⊕⊕⊕⊕
All evidenceSame as trial-only evidence
Sofosbuvir + velpatasvirTrial evidence
Everson 201548
Pianko 2015163
ASTRAL-429,37,38,146,157,228
ASTRAL-5109,146,218,219,232
POLARIS-396
ASTRAL-259,71,73,94,146,185,219,231
POLARIS-421,242
ASTRAL-359,71,73,94,146,219,231
POLARIS-296
ASTRAL-149,71,73,94,146,219,229
101524450.00 (0.00, 0.00)⊕⊕⊕⊕
All evidenceSame as trial-only evidence

From: Web Annex 3.2, Adult hepatitis C virus treatment systematic review; supporting evidence

Cover of Guidelines for the Care and Treatment of Persons Diagnosed with Chronic Hepatitis C Virus Infection
Guidelines for the Care and Treatment of Persons Diagnosed with Chronic Hepatitis C Virus Infection [Internet].
Geneva: World Health Organization; 2018 Jul.
© World Health Organization 2018.

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