Table 184Summary clinical evidence profile: Comparison 1. Cohort segregation by clinic times versus no cohort segregation

Outpatient care: Comparison 1. Cohort segregation by clinic times versus no cohort segregation
OutcomesIllustrative comparative risks (95% CI)Relative effect (95% CI)No of Participants (studies)Quality of the evidence (GRADE)Comments
Assumed riskCorresponding risk
No cohort segregationCohort segregation into different pathogens by clinic times
10-year incidence of P aeruginosa infections.
Follow-up: 10 years
778 per 1000622 per 1000
(404 to 941)
RR 0.8
(0.52 to 1.21)
39
()
⊕⊕⊝⊝
low,
4-year prevalence of MRSA (percentages)
Follow-up: 4 years
1%1.3%ns≈2,837 sputum cultures
()
⊕⊝⊝⊝
very low
4-year prevalence of non-mucoid P aeruginosa (percentages)
Follow-up: 4 years
22.3%22.7%ns≈2,837 sputum cultures
()
⊕⊝⊝⊝
very low
4-year prevalence of mucoid P aeruginosa (percentages)
Follow-up: 4 years
5.9%1.0%P=0.001≈2,837 sputum cultures
()
⊕⊝⊝⊝
very low
Staff compliance (percentages)
Follow-up: 4 years
-Adherence to the “coloured” clinic booking scheme: % of children attending the red clinic who were 5 and under: 2004: 96.8%; 2005: 97.5%; 2006: 94.4%; 2007: 95.9%Not estimableN not reported
()
⊕⊝⊝⊝
very low
Narrative data
*

The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

Abbreviations: CI: confidence interval; MRSA: methicillin-resistant S aureus; ns: not significant; RR: risk ratio

1

The quality of the evidence was downgraded by 1 due to unclear randomisation, allocation concealment, blinding, incomplete data outcome and selective reporting

2

The quality of the evidence was downgraded by 1 because the 95% CI crossed 1 default MID

3

The quality of the evidence was downgraded by 2 because of high risk of bias in relation to sample selection, comparability between groups and outcome reporting

4

Intervention group: data for the period 2004 to 2007; comparison group: data for the period 1999 to 2002. Intervention introduced in 2003.

From: 11, Prevention of cross infection

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Cystic Fibrosis: Diagnosis and management.
NICE Guideline, No. 78.
National Guideline Alliance (UK).
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