| Study | Reason for Exclusion |
|---|---|
| Abrao, M. S., Goncalves, M. O., Dias, J. A., Jr., Podgaec, S., Chamie, L. P., Blasbalg, R., Comparison between clinical examination, transvaginal sonography and magnetic resonance imaging for the diagnosis of deep endometriosis, Human Reproduction, 22, 3092–7, 2007 | Test not of interest |
| Abrao, M. S., Podgaec, S., Filho, B. M., Ramos, L. O., Pinotti, J. A., de Oliveira, R. M., The use of biochemical markers in the diagnosis of pelvic endometriosis, Human Reproduction, 12, 2523–7, 1997 | Case-control study |
| Abrao, M. S., Podgaec, S., Pinotti, J. A., de Oliveira, R. M., Tumor markers in endometriosis, International Journal of Gynaecology & Obstetrics, 66, 19–22, 1999 | Case-control study |
| Abu-Musa, A., Takahashi, K., Nagata, H., Yamasaki, H., Mizoguchi, S., Kitao, M., CA-125 in menstrual discharge in patients with chronic pelvic pain, International Journal of Gynaecology & Obstetrics, 37, 111–4, 1992 | The level of CA-125 in menstrual discharge has been assessed |
| Acimovic, M., Vidakovic, S., Milic, N., Jeremic, K., Markovic, M., Milosevic-Djeric, A., Lazovic-Radonjic, G., Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis, Journal of Medical Biochemistry, 35, 63–68, 2016 | No laparoscopy/laparotomy and no histological confirmation |
| Alcazar, J. L., Laparte, C., Jurado, M., Lopez-Garcia, G., The role of transvaginal ultrasonography combined with color velocity imaging and pulsed Doppler in the diagnosis of endometrioma, Fertility & Sterility, 67, 487–91, 1997 | Test not of interest |
| Aleem, F., Pennisi, J., Zeitoun, K., Predanic, M., The role of color Doppler in diagnosis of endometriomas, Ultrasound in Obstetrics & Gynecology, 5, 51–4, 1995 | The aim of this study is to describe vascular appearance in endometriomas. No outcome of interest. |
| Al-Jefout, M., Dezarnaulds, G., Cooper, M., Tokushige, N., Luscombe, G. M., Markham, R., Fraser, I. S., Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study, Human Reproduction (Oxford, England), 24, 3019–24, 2009 | Not a test that is routinely carried out |
| Anaf, V., El Nakadi, I., De Moor, V., Coppens, E., Zalcman, M., Noel, J. C., Anatomic significance of a positive barium enema in deep infiltrating endometriosis of the large bowel, World Journal of Surgery, 33, 822–7, 2009 | All patients had surgery and DCBE |
| Arrive, L., Hricak, H., Martin, M. C., Pelvic endometriosis: MR imaging, Radiology, 171, 687–92, 1989 | Test not of interest |
| Bagan, P., Berna, P., Assouad, J., Hupertan, V., Le Pimpec Barthes, F., Riquet, M., Value of cancer antigen 125 for diagnosis of pleural endometriosis in females with recurrent pneumothorax, European Respiratory Journal, 31, 140–2, 2008 | The control group are males |
| Balasch, J., Creus, M., Fabregues, F., Carmona, F., Ordi, J., Martinez-Roman, S., Vanrell, J. A., Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study, Human Reproduction, 11, 387–91, 1996 | Not a diagnostic study |
| Balleyguier, C., Roupret, M., Nguyen, T., Kinkel, K., Helenon, O., Chapron, C., Ureteral endometriosis: the role of magnetic resonance imaging, Journal of the American Association of Gynecologic Laparoscopists, 11, 530–6, 2004 | No outcome of interest. Moreover, only 6 patients were included |
| Barcellos, M. B., Lasmar, B., Lasmar, R., Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis, Archives of Gynecology & Obstetrics Arch Gynecol Obstet, 293, 845–50, 2016 | Lesion-level analysis |
| Bazot, M., Gasner, A., Ballester, M., Darai, E., Value of thin-section oblique axial T2-weighted magnetic resonance images to assess uterosacral ligament endometriosis, Human Reproduction, 26, 346–53, 2011 | Retrospective study; one MRI technique compared to conventional technique |
| Bazot, M., Gasner, A., Lafont, C., Ballester, M., Darai, E., Deep pelvic endometriosis: limited additional diagnostic value of postcontrast in comparison with conventional MR images, European Journal of Radiology, 80, e331–9, 2011 | Retrospective study; comparison of post-contrast MRI versus conventional MRI |
| Bedaiwy, M. A., Falcone, T., Laboratory testing for endometriosis, Clinica Chimica Acta, 340, 41–56, 2004 | Narrative review |
| Bedaiwy, M. A., Falcone, T., Sharma, R. K., Goldberg, J. M., Attaran, M., Nelson, D. R., Agarwal, A., Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial, Human Reproduction, 17, 426–31, 2002 | Biomarkers not of interest |
| Belghiti, J., Thomassin-Naggara, I., Zacharopoulou, C., Zilberman, S., Jarboui, L., Bazot, M., Ballester, M., Darai, E., Contribution of Computed Tomography Enema and Magnetic Resonance Imaging to Diagnose Multifocal and Multicentric Bowel Lesions in Patients With Colorectal Endometriosis, Journal of Minimally Invasive Gynecology, 22, 776–84, 2015 | Lesion-level analysis |
| Belli, P., De Gaetano, A. M., Mirk, P., Speca, S., Valentini, A. L., Uterine adenomyosis and tubal endometriosis: diagnostic imaging, Rays, 23, 693–701, 1998 | Narrative review |
| Benacerraf, B. R., Finkler, N. J., Wojciechowski, C., Knapp, R. C., Sonographic accuracy in the diagnosis of ovarian masses, Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 35, 491–495, 1990 | No outcome of interest |
| Benacerraf, B. R., Groszmann, Y., Sonography should be the first imaging examination done to evaluate patients with suspected endometriosis, Journal of Ultrasound in Medicine, 31, 651–3, 2012 | Narrative review |
| Bordin, L., Fiore, C., Dona, G., Andrisani, A., Ambrosini, G., Faggian, D., Plebani, M., Clari, G., Armanini, D., Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis, Fertility & Sterility, 94, 1616–21, 2010 | All the patients have proven endometriosis |
| Cheng, Y. M., Wang, S. T., Chou, C. Y., Serum CA-125 in preoperative patients at high risk for endometriosis, Obstetrics & Gynecology, 99, 375–80, 2002 | CA-125 has been used for identifying high risk woman not as a diagnostic tool |
| Cho, S., Cho, H., Nam, A., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., Lee, B. S., Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis, Fertility & Sterility, 90, 2073–9, 2008 | It is a case control-study |
| Chudecka-Glaz, A., Cymbaluk-Ploska, A., Luterek-Puszynska, K., Menkiszak, J., Diagnostic usefulness of the Risk of Ovarian Malignancy Algorithm using the electrochemiluminescence immunoassay for HE4 and the chemiluminescence microparticle immunoassay for CA125, Oncology Letters, 12, 3101–3114, 2016 | Women with no suspected endometriosis |
| Chung, M. K., Chung, R. R., Gordon, D., Jennings, C., The evil twins of chronic pelvic pain syndrome: endometriosis and interstitial cystitis, JSLS: Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons, 6, 311–314, 2002 | No outcome of interest |
| Cicinelli, E., Resta, L., Nicoletti, R., Tartagni, M., Marinaccio, M., Bulletti, C., Colafiglio, G., Detection of chronic endometritis at fluid hysteroscopy, Journal of Minimally Invasive Gynecology, 12, 514–518, 2005 | Comparison not of interest |
| Cohen, L. S., Valle, R. F., Sabbagha, R. E., A comparison of preoperative ultrasound images of surgically proven endometriomas scanned by both transabdominal and transvaginal techniques, Journal of Gynecologic Surgery, 11, 27–32, 1995 | All the patients have surgically confirmed endometriosis. |
| Cohen, M. R., Laparoscopy in the diagnosis and management of endometriosis, Journal of Reproductive Medicine, 27, 240–2, 1982 | No outcome of interest |
| Colacurci, N., Fortunato, N., De Franciscis, P., Fratta, M., Cioffi, M., Zarcone, R., Cardone, A., Serum and peritoneal CA-125 levels as diagnostic test for endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 66, 41–3, 1996 | Case-control study |
| Coleman, B. G., Arger, P. H., Mulhern, C. B., Jr., Endometriosis: clinical and ultrasonic correlation, AJR. American Journal of Roentgenology, 132, 747–9, 1979 | All patients were recruited in this study, had surgically proven endometriosis |
| Corwin, M. T., Gerscovich, E. O., Lamba, R., Wilson, M., McGahan, J. P., Differentiation of ovarian endometriomas from hemorrhagic cysts at MR imaging: utility of the T2 dark spot sign, Radiology, 271, 126–32, 2014 | Using a diagnostic test to diagnose endometriosis has not been addressed in this study. It is about a sign in MRI to distinguish between Endometrioma and haemorrhagic cysts. |
| Daniilidis, A., Giannoulis, H., Tantanasis, T., Papathanasiou, K., Loufopoulos, A., Tzafettas, J., Diagnostic laparoscopy, infertility, and endometriosis - 5 Years experience, Gynecological Surgery, 5, 231–234, 2008 | Outcomes not of interest |
| Dechaud, H., Ali Ahmed, S. A., Aligier, N., Vergnes, C., Hedon, B., Does transvaginal hydrolaparoscopy render standard diagnostic laparoscopy obsolete for unexplained infertility investigation?, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 94, 97–102, 2001 | Transvaginal hydrolaparoscopy compared with conventional laparoscopy; no data for outcomes |
| do Amaral, V. F., Ferriani, R. A., de Sa, M. F. S., Nogueira, A. A., Silva, J. C. R., de Sa Rosa e Silva, A. C. J., de Moura, M. D., Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis, Sao Paulo Medical Journal, 124, 223–227, 2006 | It is a case-control study |
| Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D’Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., Prentice, A., Saridogan, E., Soriano, D., Nelen, W., ESHRE guideline: Management of women with endometriosis, Human Reproduction, 29, 400–412, 2014 | The individual studies in this publication have been checked for inclusion in the review |
| El Maati, A. A. A., Ibrahim, E. A. G., Mokhtar, F. Z., A two-stage imaging protocol for evaluating women presenting with acute pelvic pain, Egyptian Journal of Radiology and Nuclear Medicine, 44, 923–936, 2013 | The population is women with acute pelvic pain, not suspected endometriosis |
| Elgafor El Sharkwy, I. A., Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis, Archives of gynecology and obstetrics, 288, 793–7, 2013 | The diagnostic test (IL-6 combined with nerve fibers) which has been used in this study is not matched with the protocol |
| Ellett, L., Readman, E., Newman, M., McIlwaine, K., Villegas, R., Jagasia, N., Maher, P., Are endometrial nerve fibres unique to endometriosis? A prospective case-control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain, Human Reproduction, 30, 2808–15, 2015 | Case-control study |
| Exacoustos, C., Luciano, D., Corbett, B., De Felice, G., Di Feliciantonio, M., Luciano, A., Zupi, E., The uterine junctional zone: a 3-dimensional ultrasound study of patients with endometriosis, American Journal of Obstetrics & Gynecology, 209, 248.e1–7, 2013 | In the study, the relation between thickness of uterine junctional zone and endometriosis has been evaluated. It has not been used as a diagnostic tool. |
| Faccioli, N., Manfredi, R., Mainardi, P., Dalla Chiara, E., Spoto, E., Minelli, L., Mucelli, R. P., Barium enema evaluation of colonic involvement in endometriosis, AJR. American Journal of Roentgenology, 190, 1050–4, 2008 | The diagnostic test (Barium enema) which has been used in this study is not matched with the protocol. |
| Federici, D., Muggiasca, M. L., Conti, M., Diagnostic value of laparoscopic evaluation of women with chronic pelvic pain: Our experience and a review of the literature, VALEUR DIAGNOSTIQUE DE L’EXPLORATION LAPAROSCOPIQUE DES FEMMES SOUFFRANT DE DOULEURS PELVIENNES CHRONIQUES: EXPERIENCE PERSONNELLE ET REVUE DE LA LITTERATURE, Acta Endoscopica, 22, 177–186, 1992 | Narrative review |
| Felding, C., Mikkelsen, A. L., Peen, U., Laparoscopy and ultrasound in patients with chronic pelvic pain, Journal of Obstetrics and Gynaecology, 10, 419–422, 1990 | No outcome of interest. |
| Fisk, N. M., Tan, C. E., CA 125 in peritoneal fluid and serum of patients with endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 29, 153–8, 1988 | Case-control study |
| Foda, A. A., Aal, I. A. A., Role of some biomarkers in chronic pelvic pain for early detection of endometriosis in infertile women, Middle East Fertility Society Journal, 17, 187–194, 2012 | Case-control study |
| Fratelli, N., Scioscia, M., Bassi, E., Musola, M., Minelli, L., Trivella, G., Transvaginal sonography for preoperative assessment of deep endometriosis, Journal of Clinical Ultrasound, 41, 69–75, 2013 | Data for TVS was collected retrospectively |
| Friedman, H., Vogelzang, R. L., Mendelson, E. B., Neiman, H. L., Cohen, M., Endometriosis detection by US with laparoscopic correlation, Radiology, 157, 217–20, 1985 | No data on outcomes |
| Gougoutas, C. A., Siegelman, E. S., Hunt, J., Outwater, E. K., Pelvic endometriosis: various manifestations and MR imaging findings, AJR. American Journal of Roentgenology, 175, 353–8, 2000 | Narrative review |
| Gurgan, T., Kisnisci, H., Yarali, H., Aksu, T., Zeyneloglu, H., Develioglu, O., Serum and peritoneal fluid CA-125 levels in early stage endometriosis, Gynecologic & Obstetric Investigation, 30, 105–8, 1990 | The cut-off for CA-125 is 16 U/ml |
| Guven, M. A., Bese, T., Demirkiran, F., Comparison of hydrosonography and transvaginal ultrasonography in the detection of intracavitary pathologies in women with abnormal uterine bleeding, International Journal of Gynecological Cancer, 14, 57–63, 2004 | The study population are women with history of abnormal uterine bleeding not women suspected to endometriosis. |
| Harada, T., Kubota, T., Aso, T., Usefulness of CA19–9 versus CA125 for the diagnosis of endometriosis, Fertility and Sterility, 78, 733–739, 2002 | Case-control study |
| Hompes, P. G., Koninckx, P. R., Kennedy, S., van Kamp, G. F., Verstraeten, R. A., Cornillie, F., Serum CA-125 concentrations during midfollicular phase, a clinically useful and reproducible marker in diagnosis of advanced endometriosis, Clinical Chemistry, 42, 1871–4, 1996 | No outcome of interest has been reported |
| Hornstein, M. D., Harlow, B. L., Thomas, P. P., Check, J. H., Use of a new CA 125 assay in the diagnosis of endometriosis, Human Reproduction, 10, 932–4, 1995 | The reported result has adjusted for prevalence of endometriosis in the community. This data is not useful for our systematic review |
| Howard, F. M., El-Minawi, A. M., Sanchez, R. A., Conscious pain mapping by laparoscopy in women with chronic pelvic pain, Obstetrics & Gynecology, 96, 934–9, 2000 | The study investigated conscious pain mapping using laparoscopy |
| Ikeda, F., Bernardini, M. A., Vanni, D., Vasconcelos, A., Pinotti, J. A., Abrao, M. S., A comparison of microlaparoscopy under sedation, microlaparoscopy under general anesthesia and conventional laparoscopy for diagnosis and treatment of pelvic endometriosis in early stages, Fertility and sterility, 77, S21, 2002 | The effectiveness of using a diagnostic tool for diagnosis of endometriosis has not been addressed. |
| Ismail, M. A., Rotmensch, J., Mercer, L. J., Block, B. S., Salti, G. I., Holt, J. A., CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders, Journal of Reproductive Medicine, 39, 510–2, 1994 | The women without any symptom who went through laparoscopic sterilization have been considered as control group |
| Johnson, W. K., Ott, D. J., Chen, M. Y. M., Fayez, J. A., Gelfand, D. W., Efficacy of hysterosalpingography in evaluating endometriosis, Abdominal Imaging, 19, 278–280, 1994 | The study evaluated the effectiveness of hysterosalpingography and laparoscopy-retrospective study |
| Kafali, H., Artuc, H., Demir, N., Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis; a preliminary report, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 116, 85–8, 2004 | It is a case-control study |
| Kang, S. B., Chung, H. H., Lee, H. P., Lee, J. Y., Chang, Y. S., Impact of diagnostic laparoscopy on the management of chronic pelvic pain, Surgical Endoscopy, 21, 916–9, 2007 | there was no comparison between laparoscopy and another test |
| Karabacak, O., Tiras, M. B., Taner, M. Z., Guner, H., Yildiz, A., Yildirim, M., Small diameter versus conventional laparoscopy: a prospective, self-controlled study, Human Reproduction, 12, 2399–401, 1997 | Comparison of two types of laparoscopy |
| Kitawaki, J., Ishihara, H., Koshiba, H., Kiyomizu, M., Teramoto, M., Kitaoka, Y., Honjo, H., Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas.[Erratum appears in Hum Reprod. 2007 Feb;22(2):627], Human Reproduction, 20, 1999–2003, 2005 | Women enrolled in the study were already diagnosed with endometriosis, adenomyosis and/or leiomyomas |
| Koninckx, P. R., Riittinen, L., Seppala, M., Cornillie, F. J., CA-125 and placental protein 14 concentrations in plasma and peritoneal fluid of women with deeply infiltrating pelvic endometriosis, Fertility & Sterility, 57, 523–30, 1992 | Wrong data and result have been reported. |
| Kruger, K., Behrendt, K., Niedobitek-Kreuter, G., Koltermann, K., Ebert, A. D., Location-dependent value of pelvic MRI in the preoperative diagnosis of endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 169, 93–8, 2013 | Pelvic MRI retrospectively assessed with histology |
| Kruitwagen, R. F., Thomas, C., Poels, L. G., Koster, A. M., Willemsen, W. N., Rolland, R., High CA-125 concentrations in peritoneal fluid of normal cyclic women with various infertility-related factors as demonstrated with two-step immunoradiometric assay, Fertility & Sterility, 56, 863–9, 1991 | The outcome of interest has not been reported. |
| Leslie, C., Ma, T., McElhinney, B., Leake, R., Stewart, C. J., Is the detection of endometrial nerve fibers useful in the diagnosis of endometriosis?, International Journal of Gynecological Pathology, 32, 149–55, 2013 | Included as one of the studies in Gupta et al. 2016 review |
| Li, G., Yu, Z., Li, K., The value of FS, NLR, and CA-125 in the diagnosis of endometriosis, International journal of clinical and experimental medicine, 9, 7309–7313, 2016 | Not the population of interest |
| Macer, M. L., Mathur, M., Spektor, M., Gysler, S., Staib, L., Kodaman, P., McCarthy, S., Utility of magnetic resonance imaging in the evaluation of intraoperatively confirmed pelvic adhesions, Journal of Computer Assisted Tomography, 39, 896–900, 2015 | Not the population of interest |
| Malik, E., Berg, C., Meyhofer-Malik, A., Buchweitz, O., Moubayed, P., Diedrich, K., Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid, Surgical Endoscopy, 14, 452–5, 2000 | The test is not of interest |
| Manganaro, L., Fierro, F., Tomei, A., Irimia, D., Lodise, P., Sergi, M. E., Vinci, V., Sollazzo, P., Porpora, M. G., Delfini, R., Vittori, G., Marini, M., Feasibility of 3.0T pelvic MR imaging in the evaluation of endometriosis, European Journal of Radiology, 81, 1381–7, 2012 | Women in the study already had a diagnosis of endometriosis by transvaginal ultrasound |
| Martinez, S., Garrido, N., Coperias, J. L., Pardo, F., Desco, J., Garcia-Velasco, J. A., Simon, C., Pellicer, A., Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis, Human Reproduction, 22, 836–42, 2007 | It is a case-control study |
| Mathlouthi, N., Ayed, B. B., Dhouib, M., Chaabene, K., Trabelsi, K., Amouri, H., Guermazi, M., Confrontation ultrasonography-CA125-histology in the managment of ovarian cysts: A prospective study about 77 cases, Tunisie Medicale, 89, 686–692, 2011 | Full-text in French |
| May, K. E., Conduit-Hulbert, S. A., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Peripheral biomarkers of endometriosis: a systematic review, Human Reproduction Update, 16, 651–74, 2010 | This systematic review includes papers also regarding other biomarkers. The full texts of individual related studies were retrieved and reviewed. |
| May, K. E., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Endometrial alterations in endometriosis: a systematic review of putative biomarkers, Human Reproduction Update, 17, 637–53, 2011 | Single studies from the review were assessed for inclusion |
| McBride, N., Newman, R. L., Diagnostic laparoscopy, International Journal of Gynaecology & Obstetrics, 15, 556–8, 1978 | No outcome of interest |
| McKinnon, B., Mueller, M. D., Nirgianakis, K., Bersinger, N. A., Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125, Molecular Medicine Reports, 12, 5179–84, 2015 | No data reported to calculate sensitivity |
| Medl, M., Ogris, E., Peters-Engl, C., Mierau, M., Buxbaum, P., Leodolter, S., Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis, British Journal of Obstetrics & Gynaecology, 104, 78–81, 1997 | Wrong data and result have been reported. |
| Melega, C., Marchesini, F. P., Bellettini, L., Biscontin, S., Flamigni, C., Diagnostic value of laparoscopy in endometriosis and infertility, Journal of Reproductive Medicine, 29, 597–600, 1984 | No outcome of interest |
| Mezzi, G., Ferrari, S., Arcidiacono, P. G., Di Puppo, F., Candiani, M., Testoni, P. A., Endoscopic rectal ultrasound and elastosonography are useful in flow chart for the diagnosis of deep pelvic endometriosis with rectal involvement, Journal of Obstetrics & Gynaecology Research, 37, 586–90, 2011 | There was no comparison with surgery |
| Mikami, M., Tanabe, K., Matsuo, K., Miyazaki, Y., Miyazawa, M., Hayashi, M., Asai, S., Ikeda, M., Shida, M., Hirasawa, T., Kojima, N., Sho, R., Iijima, S., Fully-sialylated alpha-chain of complement 4-binding protein: Diagnostic utility for ovarian clear cell carcinoma, Gynecologic Oncology, 139, 520–528, 2015 | Not the population of interest |
| Millischer, A. E., Salomon, L. J., Santulli, P., Borghese, B., Dousset, B., Chapron, C., Fusion imaging for evaluation of deep infiltrating endometriosis: feasibility and preliminary results, Ultrasound in Obstetrics & Gynecology, 46, 109–17, 2015 | No data on surgical diagnosis |
| Miyagi, E., Maruyama, Y., Mogami, T., Numazaki, R., Ikeda, A., Yamamoto, H., Hirahara, F., Comparison of plasma amino acid profile-based index and CA125 in the diagnosis of epithelial ovarian cancers and borderline malignant tumors, International Journal of Clinical Oncology, 1–8, 2016 | Not the population of interest |
| Mol, B. W., Bayram, N., Lijmer, J. G., Wiegerinck, M. A., Bongers, M. Y., van der Veen, F., Bossuyt, P. M., The performance of CA-125 measurement in the detection of endometriosis: a metaanalysis, Fertility & Sterility, 70, 1101–8, 1998 | All the studies included in this systematic review could not be included in our systematic review The full-texts of all individual studies were retrieved and reviewed and related studies were included in our review |
| Moloney, M. D., Thornton, J. G., Cooper, E. H., Serum CA 125 antigen levels and disease severity in patients with endometriosis, Obstetrics & Gynecology, 73, 767–9, 1989 | Women had laparoscopically confirmed endometriosis and then CA-125 level has been evaluated |
| Moretuzzo, R. W., DiLauro, S., Jenison, E., Chen, S. L., Reindollar, R. H., McDonough, P. G., Serum and peritoneal lavage fluid CA-125 levels in endometriosis, Fertility & Sterility, 50, 430–3, 1988 | No outcome of interest |
| O’Shaughnessy, A., Check, J. H., Nowroozi, K., Lurie, D., CA 125 levels measured in different phases of the menstrual cycle in screening for endometriosis, Obstetrics & Gynecology, 81, 99–103, 1993 | Wrong data and result have been reported |
| Ota, H., Maki, M., Evaluation of autoantibody and CA125 in the diagnosis of endometriosis or adenomyosis, Medical Science Research, 18, 309–310, 1990 | All the participants had known condition |
| Othman, E. E. D. R., Hornung, D., Al-Hendy, A., Biomarkers of endometriosis, Expert Opinion on Medical Diagnostics, 2, 741–752, 2008 | Narrative review |
| Ozaksit, G., Caglar, T., Cicek, N., Kuscu, E., Batioglu, S., Gokmen, O., Serum CA 125 levels before, during and after treatment for endometriosis, International Journal of Gynaecology & Obstetrics, 50, 269–73, 1995 | Women had a confirmed diagnosis of endometriosis prior to CA-125 test |
| Paiva, P., Lappas, M., Barker, G., Healey, M., Using symptom scores, lifestyle measures and biochemical markers to create a test for endometriosis, Journal of Endometriosis and Pelvic Pain Disorders, 6, 135–143, 2014 | No outcome of interest |
| Panidis, D., Vlassis, G., Matalliotakis, J., Skiadopoulos, S., Kalogeropoulos, A., Serum levels of the oncofetal antigens CA-125, CA 19–9 and CA 15–3 in patients with endometriosis, Journal of Endocrinological Investigation, 11, 801–804, 1988 | All women who involved in the study have proven endometriosis |
| Pastorfide, G., Fong, Y. F., Use of narrowband imaging for the detection of endometriosis, Journal of Minimally Invasive Gynecology, 22, 535, 2015 | No outcome of interest |
| Patel, M. D., Feldstein, V. A., Chen, D. C., Lipson, S. D., Filly, R. A., Endometriomas: diagnostic performance of US.[Erratum appears in Radiology 1999 Dec;213(3):930], Radiology, 210, 739–45, 1999 | Retrospective review of sonograms by two sonologists |
| Patel, M. D., Feldstein, V. A., Filly, R. A., The likelihood ratio of sonographic findings for the diagnosis of hemorrhagic ovarian cysts, Journal of Ultrasound in Medicine, 24, 607–14; quiz 615, 2005 | It is about diagnosis of haemorrhagic ovarian cyst not endometrioma |
| Patton, P. E., Field, C. S., Harms, R. W., Coulam, C. B., CA-125 levels in endometriosis, Fertility & Sterility, 45, 770–3, 1986 | Women who come for elective sterilization have been also included in this study, while they are not suspected for endometriosis |
| Philip, C. A., Bisch, C., Coulon, A., de Saint-Hilaire, P., Rudigoz, R. C., Dubernard, G., Correlation between three-dimensional rectosonography and magnetic resonance imaging in the diagnosis of rectosigmoid endometriosis: a preliminary study on the first fifty cases, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 187, 35–40, 2015 | MRI was the reference test |
| Piessens, S., Healey, M., Maher, P., Tsaltas, J., Rombauts, L., Can anyone screen for deep infiltrating endometriosis with transvaginal ultrasound?, Australian & New Zealand Journal of Obstetrics & Gynaecology, 54, 462–8, 2014 | Women included in the study had the ultrasound test after diagnosis of endometriosis by surgery |
| Pittaway, D. E., Douglas, J. W., Serum CA-125 in women with endometriosis and chronic pelvic pain, Fertility & Sterility, 51, 68–70, 1989 | The cut-off for CA-125 is 16 U/ml |
| Polisseni, F., Bambirra, E. A., Camargos, A. F., Detection of chronic endometritis by diagnostic hysteroscopy in asymptomatic infertile patients, Gynecologic & Obstetric Investigation, 55, 205–10, 2003 | Comparison not of interest |
| Randall, G. W., Gantt, P. A., Poe-Zeigler, R. L., Bergmann, C. A., Noel, M. E., Strawbridge, W. R., Richardson-Cox, B., Hereford, J. R., Reiff, R. H., Serum antiendometrial antibodies and diagnosis of endometriosis, American Journal of Reproductive Immunology, 58, 374–82, 2007 | The diagnostic test which has been used in this study is not matched with the protocol |
| Redwine, D. B., Ovarian endometriosis: A marker for more extensive pelvic and intestinal disease, Fertility and Sterility, 72, 310–315, 1999 | All the patients have endometriosis |
| Reid, S., Lu, C., Casikar, I., Reid, G., Abbott, J., Cario, G., Chou, D., Kowalski, D., Cooper, M., Condous, G., Prediction of pouch of Douglas obliteration in women with suspected endometriosis using a new real-time dynamic transvaginal ultrasound technique: the sliding sign, Ultrasound in Obstetrics & Gynecology, 41, 685–91, 2013 | It has focused on the pouch of Douglas obliteration not only endometriosis |
| Rosa, E. Silva A. C., Rosa, E. Silva J. C., Ferriani, R. A., Serum CA-125 in the diagnosis of endometriosis, International Journal of Gynaecology & Obstetrics, 96, 206–7, 2007 | Retrospective study. Women included in the study already had a diagnosis of endometriosis prior to serum CA-125 collection |
| Saba, L., Guerriero, S., Sulcis, R., Ajossa, S., Melis, G., Mallarini, G., Agreement and reproducibility in identification of endometriosis using magnetic resonance imaging, Acta Radiologica, 51, 573–80, 2010 | No outcome of interest |
| Saba, L., Guerriero, S., Sulis, R., Pilloni, M., Ajossa, S., Melis, G., Mallarini, G., Learning curve in the detection of ovarian and deep endometriosis by using Magnetic Resonance: comparison with surgical results, European Journal of Radiology, 79, 237–44, 2011 | The aim of the study was to determine whether diagnostic accuracy is correlated to radiologist expertise |
| Scardapane, A., Bettocchi, S., Lorusso, F., Stabile Ianora, A. A., Vimercati, A., Ceci, O., Lasciarrea, M., Angelelli, G., Diagnosis of colorectal endometriosis: contribution of contrast enhanced MR-colonography, European Radiology, 21, 1553–63, 2011 | Comparison of MRI between two radiologists |
| Scardapane, A., Lorusso, F., Scioscia, M., Ferrante, A., Stabile Ianora, A. A., Angelelli, G., Standard high-resolution pelvic MRI vs. low-resolution pelvic MRI in the evaluation of deep infiltrating endometriosis, European Radiology, 24, 2590–6, 2014 | Comparison of MRI carried out by two different radiologists |
| Schenken, R. S., Improving the diagnosis of endometriosis in adolescents, Sexuality, Reproduction and Menopause, 6, 4–8, 2008 | Narrative review |
| Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J., Barnhart, K. T., Panel of markers can accurately predict endometriosis in a subset of patients, Fertility & Sterility, 89, 1073–81, 2008 | It is a case-control study |
| Shen, A., Xu, S., Ma, Y., Guo, H., Li, C., Yang, C., Zou, S., Diagnostic value of serum CA125, CA19–9 and CA15–3 in endometriosis: A meta-analysis, Journal of International Medical Research, 43, 599–609, 2015 | It is about association of biomarkers and stage of endometriosis. No outcome of interest. |
| Somigliana, E., Vigano, P., Candiani, M., Felicetta, I., Di Blasio, A. M., Vignali, M., Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis, Fertility & Sterility, 77, 1028–31, 2002 | Women included in the study already had laparoscopy prior to CA-125 serum collection |
| Somigliana, E., Vigano, P., Tirelli, A. S., Felicetta, I., Torresani, E., Vignali, M., Di Blasio, A. M., Use of the concomitant serum dosage of CA 125, CA 19–9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions, Human Reproduction, 19, 1871–6, 2004 | Case-control study |
| Spencer, J. A., Weston, M. J., Imaging in endometriosis, Imaging, 15, 63–71, 2003 | Narrative review |
| Stowell, S. B., Wiley, C. M., Perez-Reyes, N., Powers, C. N., Cytologic diagnosis of peritoneal fluids. Applicability to the laparoscopic diagnosis of endometriosis, Acta Cytologica, 41, 817–22, 1997 | The diagnostic test in this study is not matched with the protocol |
| Szubert, M., Suzin, J., Wierzbowski, T., Kowalczyk-Amico, K., CA-125 concentration in serum and peritoneal fluid in patients with endometriosis - preliminary results, Archives of Medical Science, 8, 504–8, 2012 | Case control study |
| Takahashi, K., Nagata, H., Kitao, M., CA-125 in the menstrual blood is an effective marker for diagnosing early stage endometriosis: A preliminary report, Japanese Journal of Fertility and Sterility, 36, 356–359, 1991 | Ultrasound was used to confirm ovulatory day only |
| Takahashi, K., Nagata, H., Musa, A. A., Shibukawa, T., Yamasaki, H., Kitao, M., Clinical usefulness of CA-125 levels in the menstrual discharge in patients with endometriosis, Fertility & Sterility, 54, 360–2, 1990 | The level of CA-125 has been assessed in the menstrual discharge |
| Takeuchi, M., Matsuzaki, K., Nishitani, H., Susceptibility-weighted MRI of endometrioma: preliminary results, AJR. American Journal of Roentgenology, 191, 1366–70, 2008 | No outcome of interest |
| Tirlapur, S. A., Daniels, J. P., Khan, K. S., Medal trial collaboration, Chronic pelvic pain: how does noninvasive imaging compare with diagnostic laparoscopy?, Current Opinion in Obstetrics & Gynecology, 27, 445–8, 2015 | This systematic review has not only focused on patients with suspected endometriosis. It is more general about pelvic pain and diagnostic tools |
| Tumedei, U., Ciardelli, V., Paltrinieri, F., Kuria, M. S., Amadori, A., Stefanetti, M., Gori, G., Transvaginal ultrasound in the diagnosis of endometrial abnormalities, Tumori, 87, S15, 2001 | It has focused on endometrial abnormalities not endometriosis |
| Van den Bosch, T., Vandendael, A., Van Schoubroeck, D., Wranz, P. A. B., Lombard, C. J., Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women, Obstetrics and Gynecology, 85, 349–352, 1995 | It is not about endometriosis, it has addressed endometrial diseases |
| Vrachnis, N., Sifakis, S., Samoli, E., Kappou, D., Pavlakis, K., Iliodromiti, Z., Botsis, D., Three-dimensional ultrasound and three-dimensional power Doppler improve the preoperative evaluation of complex benign ovarian lesions, Clinical & Experimental Obstetrics & Gynecology, 39, 474–8, 2012 | No outcome of interest |
| Walsh, J. W., Taylor, K. J., Wasson, J. F., Schwartz, P. E., Rosenfield, A. T., Gray-scale ultrasound in 204 proved gynecologic masses: accuracy and specific diagnostic criteria, Radiology, 130, 391–7, 1979 | No outcome of interest. |
| Wang, L., Liu, H. Y., Shi, H. H., Lang, J. H., Sun, W., Urine peptide patterns for non-invasive diagnosis of endometriosis: a preliminary prospective study, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 177, 23–8, 2014 | Biomarker not of interest |
| Wessels, J. M., Kay, V. R., Leyland, N. A., Agarwal, S. K., Foster, W. G., Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis, Fertility & Sterility, 105, 119128.e5, 2016 | Not the test of interest |
| Wild, R. A., Hirisave, V., Bianco, A., Podczaski, E. S., Demers, L. M., Endometrial antibodies versus CA-125 for the detection of endometriosis, Fertility & Sterility, 55, 90–4, 1991 | The cut-off for CA-125 is 16 U/ml |
| Wolfler, M. M., Nagele, F., Kolbus, A., Seidl, S., Schneider, B., Huber, J. C., Tschugguel, W., A predictive model for endometriosis, Human Reproduction, 20, 1702–8, 2005 | Biomarker not of interest |
| Yamashita, Y., Torashima, M., Hatanaka, Y., Harada, M., Higashida, Y., Takahashi, M., Mizutani, H., Tashiro, H., Iwamasa, J., Miyazaki, K., et al.,, Adnexal masses: accuracy of characterization with transvaginal US and precontrast and postcontrast MR imaging, Radiology, 194, 557–65, 1995 | Review of MRI and TVUS by five radiologists |
| Yazbek, J., Helmy, S., Ben-Nagi, J., Holland, T., Sawyer, E., Jurkovic, D., Value of preoperative ultrasound examination in the selection of women with adnexal masses for laparoscopic surgery, Ultrasound in Obstetrics and Gynecology, 30, 883–888, 2007 | The preoperative sonography has not been used to diagnose endometriosis |
| Zapardiel, I., Gorostidi, M., Ravaggi, A., Allende, M. T., Silveira, M., Abehsera, D., MacUks, R., Utility Serum Marker HE4 for the Differential Diagnosis between Endometriosis and Adnexal Malignancy, International Journal of Gynecological Cancer, 26, 52–55, 2016 | No data on surgical diagnosis |
| Zhang Y, Qiao C, Li L, Zhao X, Li Y. Serum HE4 is more suitable as a biomarker than CA125 in Chinese women with benign gynecologic disorders. Afr Health Sci, 14(4):913–8, 2014 | Included in the nerve fibres question |
From: Appendix H, Excluded studies
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