Table 19, GRADE findings for association between a reactive trace and adverse neonatal outcomes - Addendum to intrapartum care: care for healthy women and babies

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Quality assessment	Definition of outcome	Stage of labour	Number of babies with defined FHR pattern	Degree of association or number (percentage) of babies with defined outcome	Quality
Reactive trace (presence of at least two accelerations (defined according to NICHD classification 2008) within a 20-minute period
1 study (Graham 2014)	Case control	Serious¹	No serious inconsistency	No serious indirectness	Serious imprecision²	Whole-body hypothermia treatment for suspected moderate to severe encephalopathy	Last 1 hour tracing before birth	64	OR^a 0.50 (95% CI 0.22–1.12)	Very low

Quality assessment

Definition of outcome

Stage of labour

Number of babies with defined FHR pattern

Degree of association or number (percentage) of babies with defined outcome

Quality

Number of studies

Design

Risk of bias

Inconsistency

Indirectness

Imprecision

Reactive trace (presence of at least two accelerations (defined according to NICHD classification 2008) within a 20-minute period

1 study

Case control

Serious¹

No serious inconsistency

No serious indirectness

Serious imprecision²

Whole-body hypothermia treatment for suspected moderate to severe encephalopathy

Last 1 hour tracing before birth

OR^a 0.50

(95% CI 0.22–1.12)

Very low

: CI confidence interval; NICHD National Institute of Child Health and Human Development; OR odds ratio
a: Adjusted for chorioamnionitis
1: High risk of bias in relation to important potential confounders (these were not appropriately accounted for, except for chorioamnionitis)
2: CI crosses 0.75

Addendum to intrapartum care: care for healthy women and babies.

Clinical Guideline, No. 190.1.

National Guideline Alliance (UK).

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