Table 55GRADE findings for distribution of fetal blood sampling findings and ST guideline indication to intervenea: marked acidosis (cord artery pH < 7.06)

Quality assessmentNumber of babies / number of fetal scalp blood samplesEffectQuality
Number of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsMarked acidosisControlRelative (95% CI)Absolute (95% CI)
Women with abnormal FBS (pH < 7.20)

1 study

(Noren 2007)

Observational studyNo serious risk of biasNo serious inconsistencySerious1No serious imprecisionNone

24/53

(45.3%)

4/53

(7.5%)

RR 6 (2.23 to 16.11)377 more per 1000 (from 93 more to 1000 more)Very low
ST indication to intervenea

1 study

(Noren 2007)

Observational studyNo serious risk of biasNo serious inconsistencySerious1No serious imprecisionNone

41/53

(77.4%)

20/53

(37.7%)

RR 2.05 (1.41 to 2.98)396 more per 1000 (from 155 more to 747 more)Very low
No ST indication to intervene (adequately monitored)

1 study

(Noren 2007)

Observational studyNo serious risk of biasNo serious inconsistencySerious1No serious imprecisionNone

5/46

(10.9%)

22/42

(52.4%)

RR 0.21 (0.09 to 0.5)414 fewer per 1000 (from 262 fewer to 477 fewer)Very low

CI confidence interval, FBS fetal blood sampling, RR relative risk

a

The ST log automatically notified the staff if any ST events occurred and intervention was required in case of combined CTG and ST changes. Intervention was also indicated by occurrence of preterminal CTG (complete loss of variability and reactivity). No intervention was recommended if CTG was normal, irrespective of the ST wave analysis.

1

Study population consisted of women with high risk pregnancy, induced labour, augmentation of labour and women with meconium stained liquor

From: Appendix I, GRADE tables

Cover of Addendum to intrapartum care: care for healthy women and babies
Addendum to intrapartum care: care for healthy women and babies.
Clinical Guideline, No. 190.1.
National Guideline Alliance (UK).
Copyright © National Institute for Health and Care Excellence 2017.

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