Table 5Included studies summary

ReferenceParticipantsIntervention and comparatorOutcomes reported

Ljotsson (2010)

ID: 2511

Andersson (2011)

ID: 252

Ljotsson (2011)c

ID: 295(a)

85 self-referred IBS-patients who self-declared to have had a previous diagnosis of IBS given by a physician and if they presently fulfilled the Rome III criteria for IBS.

Stockholm.

Intervention:

CCBT-Mindfulness/Exposure (10-week CBT-protocol)

With online therapist contact

Comparator:

Waitlist (online discussion forum) With online therapist contact

10-week treatment period with 3-month follow-up online assessment.

Outcomes (10-week and 3-month follow-up):

  • IBS-QoL
  • GSRS-IBS responder
  • GSRS-IBS scores
  • The GI symptom diary (only at 10-week)

Ljotsson (2011) b

ID: 209

61 IBS-patients consecutively recruited at a single gastroenterological clinic located in Stockholm, Sweden. Patients came to the clinic by referral or by self-referral.

Stockholm.

Intervention:

CCBT-Mindfulness/Exposure (10-week CBT-protocol)

With online therapist contact

Comparator:

Waitlist (online discussion forum)

With online therapist contact

10-week treatment period with 12-month follow-up online assessment.
  • IBS-QoL
  • GSRS-IBS scores

Ljotsson (2011)

ID: 226

195 self-referred IBS-patients who self-declared to have had a previous diagnosis of IBS given by a physician and if they presently fulfilled the Rome III criteria for IBS.

Stockholm.

Intervention:

CCBT-Mindfulness/Exposure (10-week CBT-protocol)

With online therapist contact

Comparator:

Internet-delivered stress management (ISM)

With online therapist contact

10-week treatment period with 6-month follow-up online assessment.

Outcomes (10-week and 3-month follow-up):

  • ISB-QoL
  • GSRS-IBS scores
  • Adequate relief (responder)

Gaylord (2011)

ID: 219

75 women with IBS under the care of a physician recruited through an existing registry of IBS patients interested in participating in research studies.

USA.

Intervention:

Mindfulness-based stress and pain management program (8 weekly 2-hour group session, plus one half-day retreat)

Comparator:

Social-support group

8 weeks treatment period with 10-week post-outcome assessment and then 3-month follow-up.
  • IBS-QoL
  • IBS-SS responder
  • IBS-SS scores

Zernicke (2012)

ID: 1579

90 people who received a diagnosis of IBS by a gastroenterologist 90 people who received a diagnosis of IBS by a gastroenterologist

Canada.

Intervention:

Mindfulness-Based

Stress Reduction (MBSR) (8 weekly group sessions)

Comparator: Treatment as usual

(TAU) (b)

8-week treatment period with 6 months follow-up.
  • IBS-QoL
  • IBS-SS responder
  • IBS-SS scores

Hunt (2009)

ID: 454

54 IBS patients who self-reported that they had been diagnosed with IBS by a medical professional, but were not currently diagnosed with any other GI disorder.

USA.

Intervention:

CCBT-Exposure (5-week treatment)

Comparator:

Waitlist control (basic self-monitoring, no other information provided)

5-week treatment with 3-month follow-up (only incomplete 3-month data was reported).

At 6-week assessment:

  • IBS-QoL
  • GSRS-IBS scores

Ljotsson (2014)

ID: 1535

311 self-referred IBS patients who declared to have had a previous diagnosis of IBS given by a physician, presently fulfilled the Rome III-criteria for IBS.

Sweden.

Intervention:

CCBT-Mindfulness (10-week CBT protocol)

Comparator:

CCBT-Mindfulness/Exposure (10-week CBT protocol)

10-week treatment with 6-month follow-up.
  • IBS-QoL
  • GSRS-IBS scores
  • Adverse events
(a)

3 publications of one study;

(b)

No definition for treatment as usual.

From: 2, Evidence review and recommendations

Cover of Addendum to NICE guideline CG61, Irritable bowel syndrome in adults
Addendum to NICE guideline CG61, Irritable bowel syndrome in adults: Diagnosis and management of irritable bowel syndrome in primary care.
NICE guideline, No. CG61.1.
Copyright © National Institute for Health and Care Excellence, 2015.

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