| Outcomes | No of Participants (studies) Follow up | Quality of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects | |
|---|---|---|---|---|---|
| Risk with Control | Risk difference with Regional with nerve block versus general with nerve block (95% CI) | ||||
| Mortality | Not reported | ||||
| Quality of life | Not reported | ||||
|
Postoperative pain Defence and Veterans Pain Rating Scale. Scale from: 0 to 10. |
88 (1 study) 1 days |
⊕⊕⊕⊝ MODERATE1 due to imprecision |
The mean postoperative pain in the control groups was 3.3 |
The mean postoperative pain in the intervention groups was 0.4 lower (1.24 lower to 0.44 higher) | |
| Postoperative neurocognitive decline | Not reported | ||||
| Thromboembolic complications | Not reported | ||||
| Hospital readmission | Not reported | ||||
| Length of stay |
88 (1 study) |
⊕⊕⊕⊕ HIGH |
The mean length of stay in the control groups was 53 hours |
The mean length of stay in the intervention groups was 2 lower (13.84 lower to 9.84 higher) | |
|
Mobilisation ambulation distance on postoperative day 1 |
88 (1 study) |
⊕⊕⊕⊝ MODERATE2 due to risk of bias |
The mean mobilisation in the control groups was 218 metres |
The mean mobilisation in the intervention groups was 17 higher (39.45 lower to 73.45 higher) | |
Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs.
Downgraded by 1 increment if the majority of the evidence was at high risk of bias and downgraded by 2 increments if the majority of the evidence was at very high risk of bias.
From: Evidence review for anaesthesia for knee replacement
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