[Table], Outcomes during treatment of DKA - Evidence reviews for fluid therapy for the management of diabetic ketoacidosis

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Outcomes during treatment of DKA

No. of studies	Study design	Sample size	Effect size (95% CI)	Quality	Interpretation of effect
Healthcare utilisation- Mean PICU length of stay (hours) -MD less than 0 favours 0.9% saline
Basnet 2014	Retrospective cohort study	88	MD: 2.00 (−1.01, 5.01)	Low	Could not differentiate between IV fluids
Rate of change of glucose (mg/dL/h) - MD greater than 0 favours 0.9% saline
Basnet 2014	Retrospective cohort study	88	MD: −7.70 (−18.02, 2.62)	Low	Could not differentiate between IV fluids
Change in corrected sodium from baseline (meq/L) -MD greater than 0 favours 0.9% saline
Basnet 2014	Retrospective cohort study	88	MD:3.50 (1.43, 5.57)	Low	0.9% saline favoured

From: Evidence reviews for fluid therapy for the management of diabetic ketoacidosis

Cover of Evidence reviews for fluid therapy for the management of diabetic ketoacidosis

Evidence reviews for fluid therapy for the management of diabetic ketoacidosis: Diabetes (type 1 and type 2) in children and young people: diagnosis and management: Evidence review A.

NICE Guideline, No. 18.

London: National Institute for Health and Care Excellence (NICE); 2020 Dec.

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