IV fluids + Additives

ReferenceStudy typePopulationInterventionComparatorOutcomesFurther notes
Green 1998 Retrospective cohort studyChildren aged 15 years or younger with a hospital diagnosis of severe DKA

Sodium bicarbonate

Children received standard DKA therapy with hydration and intravenous insulin infusion. Adjunctive bicarbonate therapy was administered by treating physicians in doses ranging from 7 to 238 mEq and from 0.53 to 7.37 mEq/kg (mean 2.08, median 1.66 mEq

No sodium bicarbonate

Children received standard DKA therapy with hydration and intravenous insulin infusion.
  • Cerebral oedema
  • Duration of hospitalisation
  • Children with severe DKA DKA protocol not defined.
  • Includes participants with severe DKA
Mar 1981 Retrospective cohort studyChildren with diabetes with DKA with at least one episode of DKA

Sodium bicarbonate and saline and lactate Ringers or sodium bicarbonate and Lactate Ringers

IV solution with sodium bicarbonate

No information about DKA protocol provided.

Lactate Ringers or Lactate Ringers with saline

No sodium bicarbonate

No information about DKA protocol provided.
  • Length of stay (days)
  • Duration of acidosis (hours)
  • DKA protocol not defined.
  • Includes participants with all severities of DKA

From: Evidence reviews for fluid therapy for the management of diabetic ketoacidosis

Cover of Evidence reviews for fluid therapy for the management of diabetic ketoacidosis
Evidence reviews for fluid therapy for the management of diabetic ketoacidosis: Diabetes (type 1 and type 2) in children and young people: diagnosis and management: Evidence review A.
NICE Guideline, No. 18.
Copyright © NICE 2020.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.