Table 16Clinical evidence summary: People with severe aortic stenosis vs control

OutcomesNo of Participants (studies) Follow upQuality of the evidence (GRADE)Relative effect (95% CI)Anticipated absolute effects
Risk with ControlRisk difference with Severe aortic stenosis (95% CI)
prevalence OSA2

67

(1 study)

⊕⊝⊝⊝

VERY LOW1

due to risk of bias

RR 0.56

(0.34 to 0.92)

Moderate
640 per 1000

282 fewer per 1000

(from 51 fewer to 422 fewer)2

1

Risk of bias was assessed using the QUIPS checklist. Downgraded by 1 increment if the majority of the evidence was at high risk of bias and downgraded by 2 increments if the majority of the evidence was at very high risk of bias.

2

GC considered the clinical importance of the effect estimate for each analysis on a case by case basis, taking into consideration the increment of the risk factor and the outcome under study.

From: When to suspect OSAHS, OHS and COPD–OSAHS overlap syndrome

Cover of When to suspect OSAHS, OHS and COPD–OSAHS overlap syndrome
When to suspect OSAHS, OHS and COPD–OSAHS overlap syndrome: Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s: Evidence review A.
NICE Guideline, No. 202.
National Guideline Centre (UK).
Copyright © NICE 2021.

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