Table 17Clinical evidence summary: People with Down’s syndrome vs control

OutcomesNo of Participants (studies) Follow upQuality of the evidence (GRADE)Median and rangeAnticipated absolute effects
Risk with ControlRisk difference with Downs syndrome (95% CI)
Mean AHI

64

(1 study)

VERY LOW1

due to risk of bias

Down’s syndrome: 37 (0-118)

Control: 16 (0-148)

Not estimable2
1

Risk of bias was assessed using the QUIPS checklist. Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias; no indirectness

2

Data not in an analysable format. Reported as in the paper.

From: When to suspect OSAHS, OHS and COPD–OSAHS overlap syndrome

Cover of When to suspect OSAHS, OHS and COPD–OSAHS overlap syndrome
When to suspect OSAHS, OHS and COPD–OSAHS overlap syndrome: Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s: Evidence review A.
NICE Guideline, No. 202.
National Guideline Centre (UK).
Copyright © NICE 2021.

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