Table 5Clinical evidence summary: People with severe asthma vs People without asthma

OutcomesNo of Participants (studies) Follow upQuality of the evidence (GRADE)Relative effect (95% CI)Anticipated absolute effects
Risk with No asthmaRisk difference with Severe asthma (95% CI)
prevalence of OSA -total AHI >15 events/hour

52

(1 study)

⊕⊝⊝⊝

VERY LOW1

due to risk of bias

RR 2.88

(1.59 to 5.2)

Moderate
308 per 1000

579 more per 1000

(from 182 more to 1000 more)2

1

Risk of bias was assessed using the QUIPS checklist. Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias

2

GC considered the clinical importance of the effect estimate for each analysis on a case by case basis, taking into consideration the increment of the risk factor and the outcome under study.

From: When to suspect OSAHS, OHS and COPD–OSAHS overlap syndrome

Cover of When to suspect OSAHS, OHS and COPD–OSAHS overlap syndrome
When to suspect OSAHS, OHS and COPD–OSAHS overlap syndrome: Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s: Evidence review A.
NICE Guideline, No. 202.
National Guideline Centre (UK).
Copyright © NICE 2021.

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