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Table 10. Chronic Graft-Versus-Host Disease (GVHD) Symptoms in the Lung, Muscles, Fascia, Joints, Hematopoietic and Immune Systems, and Other Symptomsa
| Organ or Site | Diagnosticb | Distinctivec | Other Featuresd | Common (Seen With Both Acute and Chronic GVHD) |
|---|---|---|---|---|
| Lung | Bronchiolitis obliterans diagnosed with lung biopsy | Bronchiolitis obliterans diagnosed with PFTs and radiologyf | BOOP | |
| Muscles, fascia, joints | Fasciitis | Myositis or polymyositisf | Edema | |
| Muscle cramps | ||||
| Arthralgia or arthritis | ||||
| Hematopoietic and immune | Thrombocytopenia | |||
| Eosinophilia | ||||
| Lymphopenia | ||||
| Hypo- or hypergammaglobulinemia | ||||
| Autoantibodies (AIHA and ITP) | ||||
| Other | Pericardial or pleural effusions | |||
| Ascites | ||||
| Peripheral neuropathy | ||||
| Nephrotic syndrome | ||||
| Myasthenia gravis | ||||
| Cardiac conduction abnormality or cardiomyopathy | ||||
AIHA = autoimmune hemolytic anemia; BOOP = bronchiolitis obliterans–organizing pneumonia; ITP = idiopathic thrombocytopenic purpura; PFTs = pulmonary function tests.
a–fSee definitions in Table 6.