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Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 3. TMA Harmonization Panel Consensus Recommended Diagnostic Criteria, Modified Jodele Criteriaa
| Biopsy-proven disease (kidney or GI) OR | |
|---|---|
| Clinical criteria: Must meet ≥4 of the following 7 criteria within 14 days at 2 consecutive time points | |
| Anemiab | Defined as one of the following: |
| 1. Failure to achieve transfusion independence for pRBCs despite evidence of neutrophil engraftment | |
| 2. Hemoglobin decline from patient’s baseline by 1 g/dL | |
| 3. New onset of transfusion dependence | |
| Rule out other causes of anemia, such as AIHA and PRCA | |
| Thrombocytopeniab | Defined as one of the following: |
| 1. Failure to achieve platelet engraftment | |
| 2. Higher than expected platelet transfusion needs | |
| 3. Refractoriness to platelet transfusion | |
| 4. 50% reduction or greater in baseline platelet count after full platelet engraftment | |
| Elevated LDH | >ULN for age |
| Schistocytes | Present |
| Hypertension | >99th percentile for age (<18 y), or systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg (≥18 y) |
| Elevated sC5b-9 | ≥ULN |
| Proteinuria | ≥1 mg/mg rUPCR |
AIHA = autoimmune hemolytic anemia; BP = blood pressure; GI = gastrointestinal; LDH = lactate dehydrogenase; pRBCs = packed red blood cells; PRCA = pure red cell aplasia; rUPCR = random urine protein to creatinine ratio; ULN = upper limit of normal.
aReprinted with permission from Schoettler et al., which is available under the Creative Commons CC-BY-NC-ND license.[43]
bIndicates clarification from published Jodele et al. criteria.[45]