PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Table 1. Definitions of Comorbidities Included in the Hematopoietic Cell Transplant–Specific Comorbidity Index (HCT-CI)a
| HCT-CI Score | ||
|---|---|---|
| 1 | 2 | 3 |
| Arrhythmia: Atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias | Moderate pulmonary: DLCO and/or FEV1 66%–80% or dyspnea on slight activity | Heart valve disease: Excluding mitral valve prolapse |
| Cardiac: Coronary artery disease,b congestive heart failure, myocardial infarction, or ejection fraction ≤50% | Moderate/severe renal: Serum creatinine >2 mg/dL, on dialysis, or prior renal transplant | Moderate/severe hepatic: Liver cirrhosis, bilirubin >1.5 × ULN, or AST/ALT >2.5 × ULN |
| Cerebrovascular disease: Transient ischemic attack or cerebrovascular accident | Peptic ulcer: Requiring treatment | Prior solid tumor: Treated at any time in the patient’s history, excluding nonmelanoma skin cancer |
| Diabetes: Requiring treatment with insulin or oral hypoglycemic agents but not diet alone | Rheumatologic: Systemic lupus erythematosus, rheumatoid arthritis, polymyositis, mixed connective tissue disease, or polymyalgia rheumatica | Severe pulmonary: DLCO and/or FEV1 <65% or dyspnea at rest or requiring oxygen |
| Hepatic, mild: Chronic hepatitis, bilirubin >ULN or AST/ALT >ULN to 2.5 × ULN | ||
| Infection: Requiring continuation of antimicrobial treatment after day 0 | ||
| Inflammatory bowel disease: Crohn disease or ulcerative colitis | ||
| Obesity: Body mass index >35 kg/m2 | ||
| Psychiatric disturbance: Depression or anxiety requiring psychiatric consult or treatment | ||
AST/ALT = aspartate aminotransferase/alanine aminotransferase; DLCO = diffusion capacity of carbon monoxide; FEV1 = forced expiratory volume in one second; ULN = upper limit of normal.
aAdapted from Sorror et al.[1]
bOne-or-more–vessel coronary artery stenosis requiring medical treatment, stent, or bypass graft.