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Table 9UK costs of anticoagulant and antiplatelet drugs
Drug class | Drug | Daily dose | Cost – per day |
---|---|---|---|
Vitamin K antagonist | Warfarin tablet | 5mg daily(a) | £0.01 |
Acenocoumarol | 4mg daily(b) | £0.18 | |
Phenindione | 100mg daily(c) | £76.88 | |
Direct acting anticoagulants (DOACs) | Dabigatran capsule | 110mg-150mg twice daily | £1.70 |
Rivaroxaban tablet | 20mg once daily | £1.80 | |
Apixaban tablet | 2.5-5mg twice daily | £1.90 | |
Edoxaban tablet | 60mg once daily | £1.75 | |
Antiplatelet | Aspirin tablet | 75mg once daily | £0.05 |
Clopidogrel | 75mg once daily | £0.05 | |
Ticagrelor | 90mg twice daily(d) | £1.95 | |
Prasugrel | 5mg once daily(e) | £1.70 |
Source: BNF 201937
- (a)
Assumed here to be an average daily dose of 5mg. Initially 5–10 mg, to be taken on day 1; subsequent doses dependent on the prothrombin time, reported as INR (international normalised ratio), a lower induction dose can be given over 3–4 weeks in patients who do not require rapid anticoagulation, elderly patients to be given a lower induction dose; maintenance 3–9 mg daily, to be taken at the same time each day.
- (b)
4mg used for calculation but BNF states daily dose is 1-8mg depending on response.
- (c)
100mg daily dose used for calculation but guidance is for 50-100mg
- (d)
180mg loading dose also required
- (e)
Based on guidance for >75 year olds. 60mg loading dose also required
Evidence review for anticoagulant and/or antiplatelet therapy for biological prosthetic valves and after valve repair: Heart valve disease presenting in adults: investigation and management: Evidence review J.
NICE Guideline, No. 208.
National Guideline Centre (UK).
London: National Institute for Health and Care Excellence (NICE); 2021 Nov.
Copyright © NICE 2021.