Table 9UK costs of anticoagulant and antiplatelet drugs

Drug classDrugDaily doseCost – per day
Vitamin K antagonistWarfarin tablet5mg daily(a)£0.01
Acenocoumarol4mg daily(b)£0.18
Phenindione100mg daily(c)£76.88
Direct acting anticoagulants (DOACs)Dabigatran capsule110mg-150mg twice daily£1.70
Rivaroxaban tablet20mg once daily£1.80
Apixaban tablet2.5-5mg twice daily£1.90
Edoxaban tablet60mg once daily£1.75
AntiplateletAspirin tablet75mg once daily£0.05
Clopidogrel75mg once daily£0.05
Ticagrelor90mg twice daily(d)£1.95
Prasugrel5mg once daily(e)£1.70

Source: BNF 201937

(a)

Assumed here to be an average daily dose of 5mg. Initially 5–10 mg, to be taken on day 1; subsequent doses dependent on the prothrombin time, reported as INR (international normalised ratio), a lower induction dose can be given over 3–4 weeks in patients who do not require rapid anticoagulation, elderly patients to be given a lower induction dose; maintenance 3–9 mg daily, to be taken at the same time each day.

(b)

4mg used for calculation but BNF states daily dose is 1-8mg depending on response.

(c)

100mg daily dose used for calculation but guidance is for 50-100mg

(d)

180mg loading dose also required

(e)

Based on guidance for >75 year olds. 60mg loading dose also required

From: Evidence review for anticoagulant and/or antiplatelet therapy for biological prosthetic valves and after valve repair

Cover of Evidence review for anticoagulant and/or antiplatelet therapy for biological prosthetic valves and after valve repair
Evidence review for anticoagulant and/or antiplatelet therapy for biological prosthetic valves and after valve repair: Heart valve disease presenting in adults: investigation and management: Evidence review J.
NICE Guideline, No. 208.
National Guideline Centre (UK).
Copyright © NICE 2021.

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