Table 9, Last searched on 22 March 2018 - Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity

#	Searches
1	exp Cerebral Palsy/ use prmz
2	exp cerebral palsy/ use oemezd
3	((cerebral or brain or central) adj2 (pal* or paralys#s or pares#s)).tw.
4	cerebral palsy.ti,ab.
5	little? disease.tw.
6	((hemipleg* or dipleg* or tripleg* or quadripleg* or unilateral) adj5 spastic).tw.
7	((hemipleg* or dipleg* or tripleg* or quadripleg* or unilateral) adj3 ataxi).tw.
8	or/1–6
9	limit 8 to english language
10	limit 9 to (adult <18 to 64 years> or aged <65+ years>) use oemezd [Limit not valid in Ovid MEDLINE(R),Ovid MEDLINE(R) In-Process; records were retained]
11	limit 9 to “all adult (19 plus years)” [Limit not valid in Embase; records were retained]
12	11 use prmz
13	or/10,12
14	exp Muscle Spasticity/ use prmz
15	exp spasticity/ use oemezd
16	spastic*.tw.
17	exp Dystonia/
18	dystoni*.ti,ab.
19	abnormal muscle tone.ti,ab.
20	14 or 15 or 16 or 17 or 18 or 19
21	exp Muscle Spasticity/ or exp Dystonia/ or exp Infusion Pumps, Implantable/ or exp Physical Therapy Modalities/ or exp Rhizotomy/ or exp Splints/ or exp Orthotic Devices/ or exp Deep Brain Stimulation/ or exp Baclofen/ad, ae, tu or exp Botulinum Toxins/ad, ae, tu or exp Diazepam/ad, ae, tu or exp Cannabinoids/ad, ae, tu or exp Acetylcholine Release Inhibitors/ad, ae, tu or exp Muscle Relaxants, Central/ad, ae, tu or exp Levodopa/ad, ae, tu or exp Dantrolene/ad, ae, tu or exp Clonazepam/ad, ae, tu or exp Pregabalin/ad, ae, tu or exp Clonidine/ad, ae, tu or exp Trihexyphenidyl/ad, ae, tu or exp Tetrabenazine/ad, ae, tu or exp Anti-Dyskinesia Agents/ad, ae, tu
22	21 use prmz
23	exp implantable infusion pump/ or exp physiotherapy/ or exp dorsal rhizotomy/ or exp splint/ or exp orthosis/ or exp brain depth stimulation/ or exp baclofen/ae, ad, cb, dt or exp botulinum toxin/ae, ad, cb, dt or exp diazepam/ae, ad, cb, dt or exp cannabinoid/ae, ad, cb, dt or exp acetylcholine release inhibitor/ae, ad, cb, dt or exp central muscle relaxant/ae, ad, cb, dt or exp levodopa/ae, ad, cb, dt or exp tizanidine/ae, ad, cb, dt or exp gabapentin/ae, ad, cb, dt or exp dantrolene/ae, ad, cb, dt or exp clonazepam/ae, ad, cb, dt or exp pregabalin/ae, ad, cb, dt or exp clonidine/ae, ad, cb, dt or exp trihexyphenidyl/ae, ad, cb, dt or exp tetrabenazine/ae, ad, cb, dt
24	23 use oemezd
25	(physiotherap* or botulinum or baclofen or tizanidine or intrathecal baclofen pump or gabapentin or levodopa or dantrolene or clonazepam or pregabalin or clonidine or dorsal rhizotomy or tetrabenazine or trihexyphenidyl or lycra or DBS or deep brain stimulat* or splint* or serial cast*).ti,ab.
26	22 or 24 or 25
27	13 and 20
28	13 and 26
29	27 or 28
30	conference abstract.pt. use oemezd
31	letter.pt. or LETTER/ use oemezd
32	Letter/ use prmz
33	EDITORIAL/ use prmz
34	editorial.pt. use oemezd
35	NEWS/ use prmz
36	exp HISTORICAL ARTICLE/ use prmz
37	note.pt. use oemezd
38	ANECDOTES AS TOPIC/ use prmz
39	COMMENT/ use prmz
40	CASE REPORT/ use prmz
41	CASE REPORT/ use oemezd
42	CASE STUDY/ use oemezd
43	(letter or comment* or abstracts).ti.
44	or/30–43
45	RANDOMIZED CONTROLLED TRIAL/ use prmz
46	RANDOMIZED CONTROLLED TRIAL/ use oemezd
47	random*.ti,ab.
48	or/45–47
49	44 not 48
50	ANIMALS/ not HUMANS/ use prmz
51	ANIMAL/ not HUMAN/ use oemezd
52	exp ANIMALS, LABORATORY/ use prmz
53	exp ANIMAL EXPERIMENTATION/ use prmz
54	exp MODELS, ANIMAL/ use prmz
55	exp RODENTIA/ use prmz
56	NONHUMAN/ use oemezd
57	exp ANIMAL EXPERIMENT/ use oemezd
58	exp EXPERIMENTAL ANIMAL/ use oemezd
59	ANIMAL MODEL/ use oemezd
60	exp RODENT/ use oemezd
61	(rat or rats or mouse or mice).ti.
62	or/49–61
63	29 not 62
64	remove duplicates from 63

Searches

exp Cerebral Palsy/ use prmz

exp cerebral palsy/ use oemezd

((cerebral or brain or central) adj2 (pal* or paralys#s or pares#s)).tw.

cerebral palsy.ti,ab.

little? disease.tw.

((hemipleg* or dipleg* or tripleg* or quadripleg* or unilateral*) adj5 spastic*).tw.

((hemipleg* or dipleg* or tripleg* or quadripleg* or unilateral*) adj3 ataxi*).tw.

or/1–6

limit 8 to english language

limit 9 to (adult <18 to 64 years> or aged <65+ years>) use oemezd [Limit not valid in Ovid MEDLINE(R),Ovid MEDLINE(R) In-Process; records were retained]

limit 9 to “all adult (19 plus years)” [Limit not valid in Embase; records were retained]

11 use prmz

or/10,12

exp Muscle Spasticity/ use prmz

exp spasticity/ use oemezd

spastic*.tw.

exp Dystonia/

dystoni*.ti,ab.

abnormal muscle tone.ti,ab.

14 or 15 or 16 or 17 or 18 or 19

exp Muscle Spasticity/ or exp Dystonia/ or exp Infusion Pumps, Implantable/ or exp Physical Therapy Modalities/ or exp Rhizotomy/ or exp Splints/ or exp Orthotic Devices/ or exp Deep Brain Stimulation/ or exp Baclofen/ad, ae, tu or exp Botulinum Toxins/ad, ae, tu or exp Diazepam/ad, ae, tu or exp Cannabinoids/ad, ae, tu or exp Acetylcholine Release Inhibitors/ad, ae, tu or exp Muscle Relaxants, Central/ad, ae, tu or exp Levodopa/ad, ae, tu or exp Dantrolene/ad, ae, tu or exp Clonazepam/ad, ae, tu or exp Pregabalin/ad, ae, tu or exp Clonidine/ad, ae, tu or exp Trihexyphenidyl/ad, ae, tu or exp Tetrabenazine/ad, ae, tu or exp Anti-Dyskinesia Agents/ad, ae, tu

21 use prmz

exp implantable infusion pump/ or exp physiotherapy/ or exp dorsal rhizotomy/ or exp splint/ or exp orthosis/ or exp brain depth stimulation/ or exp baclofen/ae, ad, cb, dt or exp botulinum toxin/ae, ad, cb, dt or exp diazepam/ae, ad, cb, dt or exp cannabinoid/ae, ad, cb, dt or exp acetylcholine release inhibitor/ae, ad, cb, dt or exp central muscle relaxant/ae, ad, cb, dt or exp levodopa/ae, ad, cb, dt or exp tizanidine/ae, ad, cb, dt or exp gabapentin/ae, ad, cb, dt or exp dantrolene/ae, ad, cb, dt or exp clonazepam/ae, ad, cb, dt or exp pregabalin/ae, ad, cb, dt or exp clonidine/ae, ad, cb, dt or exp trihexyphenidyl/ae, ad, cb, dt or exp tetrabenazine/ae, ad, cb, dt

23 use oemezd

(physiotherap* or botulinum or baclofen or tizanidine or intrathecal baclofen pump or gabapentin or levodopa or dantrolene or clonazepam or pregabalin or clonidine or dorsal rhizotomy or tetrabenazine or trihexyphenidyl or lycra or DBS or deep brain stimulat* or splint* or serial cast*).ti,ab.

22 or 24 or 25

13 and 20

13 and 26

27 or 28

conference abstract.pt. use oemezd

letter.pt. or LETTER/ use oemezd

Letter/ use prmz

EDITORIAL/ use prmz

editorial.pt. use oemezd

NEWS/ use prmz

exp HISTORICAL ARTICLE/ use prmz

note.pt. use oemezd

ANECDOTES AS TOPIC/ use prmz

COMMENT/ use prmz

CASE REPORT/ use prmz

CASE REPORT/ use oemezd

CASE STUDY/ use oemezd

(letter or comment* or abstracts).ti.

or/30–43

RANDOMIZED CONTROLLED TRIAL/ use prmz

RANDOMIZED CONTROLLED TRIAL/ use oemezd

random*.ti,ab.

or/45–47

44 not 48

ANIMALS/ not HUMANS/ use prmz

ANIMAL/ not HUMAN/ use oemezd

exp ANIMALS, LABORATORY/ use prmz

exp ANIMAL EXPERIMENTATION/ use prmz

exp MODELS, ANIMAL/ use prmz

exp RODENTIA/ use prmz

NONHUMAN/ use oemezd

exp ANIMAL EXPERIMENT/ use oemezd

exp EXPERIMENTAL ANIMAL/ use oemezd

ANIMAL MODEL/ use oemezd

exp RODENT/ use oemezd

(rat or rats or mouse or mice).ti.

or/49–61

29 not 62

remove duplicates from 63

From: Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity

Cover of Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity

Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity: Cerebral palsy in adults: Evidence review A2.

NICE Guideline, No. 119.

National Guideline Alliance (UK).

London: National Institute for Health and Care Excellence (NICE); 2019 Jan.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Table 9Last searched on 22 March 2018