Table 1Summary of the protocol (PICO table)

PopulationAdults aged 19 and over with cerebral palsy and spasticity with or without dystonia
Intervention
  • Intrathecal baclofen pump
  • Selective dorsal rhizotomy
Comparison
  • Usual care (including, for example: oral drugs, botulinum toxin and physiotherapy)
  • Placebo
OutcomeCritical
  • Walking (for ambulant people only)
  • Gross motor function (both upper / lower limb)
  • Tone (for example Ashworth scale)
  • Health related quality of life
Important
  • Pain
  • Adverse events (CSF leakage, infection, respiratory depression, baclofen withdrawal and baclofen overdose)
  • Satisfaction (patient or carer reported)
  • Use of concurrent medications

CSF: cerebrospinal fluid.

From: Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity

Cover of Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity
Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity: Cerebral palsy in adults: Evidence review A2.
NICE Guideline, No. 119.
National Guideline Alliance (UK).
Copyright © NICE 2019.

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