Table 4Summary clinical evidence profile: Comparison 2: selective dorsal rhizotomy – pre-operative versus post-operative

OutcomesIllustrative comparative risks (95% CI)Relative effect (95% CI)No of participants (studies)Quality of the evidence (GRADE)
Risk with pre-operativeRisk with Selective dorsal rhizotomy (post-operative)

Walking Self rated ambulatory ability on visual analogue scale

Scale from: 0 to 10

Follow-up: 5 years

The mean walking score was 6The mean walking - in the intervention group was 2.3 higher (2 lower to 6.6 higher)-

21

(1 observational study)

Very low1

Walking Walking, running & jumping dimension of GMFM

Scale from: 0 to 100

f Follow-up: 5 years

The mean GMFM walking scale was 65.57The mean walking in the intervention group was 15.09 higher (6.1 higher to 24.08 higher)-

7

(1 observational study)

Very low2

Gross Motor Function Measure (GMFM)

Scale from: 0 to 100

follow up: 4 months

The mean gross motor function was 87.14The mean gross motor function in the intervention group was 6.25 higher (1.73 lower to 14.23 higher)-

7

(1 observational study)

Very low1

Gross motor function Jebsen-Taylor hand function test

Scale from: 0 to 720

Follow-up: 15 months

The mean gross motor function was 72The mean gross motor function in the intervention group was 35.29 lower (55.71 lower to 14.87 lower)-

7

(1 observational study)

Very low2

Tone - hip adductors Modified Ashworth score

Scale from: 1 to 4

Follow-up: 4 months

The mean tone - hip adductors was 2.16The mean tone - hip adductors in the intervention group was 2.11 lower (2.8 lower to 1.42 lower)-

19

(1 observational study)

Very low2

Tone - hamstrings Modified Ashworth score

Scale from: 1 to 4

follow up: 4 months

The mean tone - hamstrings was 3.58The mean tone - hamstrings in the intervention group was 3.47 lower (3.83 lower to 3.11 lower)-

19

(1 observational study)

Very low2

Tone - gastroc / soleus Modified Ashworth score

Scale from: 1 to 4

Follow-up: 4 months

The mean tone - gastroc / soleus was 3.25The mean tone - gastroc / soleus in the intervention group was 2.96 lower (3.52 lower to 2.4 lower)-

19

(1 observational study)

Very low2

Tone - wrist flexors Ashworth score

Scale from: 1 to 5

Follow-up: 15 months

The mean tone - wrist flexors was 3.5The mean tone - wrist flexors in the intervention group was 2.5 lower (3.6 lower to 1.4 lower)-

6

(1 observational study)

Very low2

Tone - digital flexors Ashworth score

Scale from: 1 to 5

Follow-up: 15 months

The mean tone - digital flexors was 3.42The mean tone - digital flexors in the intervention group was 2.28 lower (3.25 lower to 1.3 lower)-

7

(1 observational study)

Very low2

Health related quality of life Self rated visual analogue scale

Scale from: 0 to 10

Follow-up: 5 years

The mean quality of life was 6.9The mean quality of life in the intervention group was 2 higher (2.3 lower to 6.3 higher)-

21

(1 observational study)

Very low1

Pain Self rated visual analogue scale

Scale from: 0 to 10

Follow-up: 5 years

The mean pain was 4The mean pain in the intervention group was 1.9 lower (9.61 lower to 5.81 higher)-

21

(1 observational study)

Very low1
Adverse events - not reported-----
Satisfaction - not reported-----
Concurrent medications - not reported-----

CI: confidence interval; GMFM, gross motor function measure; MID: minimally important difference.

1

Confidence interval includes one default MID threshold

2

Number of participants <400

From: Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity

Cover of Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity
Management of abnormal muscle tone: neurosurgical procedures to reduce spasticity: Cerebral palsy in adults: Evidence review A2.
NICE Guideline, No. 119.
National Guideline Alliance (UK).
Copyright © NICE 2019.

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