From: Pharmacological interventions
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Outcomes | No of Participants (studies*) Follow up | Quality of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects | |
---|---|---|---|---|---|
Risk with Control | Risk difference with Combined antidepressants (fluoxetine) & graded exercise versus graded exercise (95% CI) | ||||
Fatigue: 14-item Chalder fatigue scale Scale from: not reported. |
67 (1 study) 26 weeks |
⊕⊝⊝⊝ due to risk of bias, indirectness |
The mean fatigue: 14-item chalder fatigue scale at 26 weeks in the control groups was −5.7 |
The mean fatigue: 14-item chalder fatigue scale at 26 weeks in the intervention group was 0.3 lower (5.41 lower to 4.81 higher) | |
Psychological status: HADS depression Scale from: 0 to 21. |
67 (1 study) 26 weeks |
⊕⊝⊝⊝ due to risk of bias, indirectness, imprecision |
The mean psychological status: hads depression at 26 weeks in the control groups was −1.2 |
The mean psychological status: hads depression at 26 weeks in the intervention group was 0.8 lower (2.52 lower to 0.92 higher) | |
Exercise performance measure: VO2 max (mL O2/kg/min) |
67 (1 study) 26 weeks |
⊕⊝⊝⊝ due to risk of bias, indirectness, imprecision |
The mean change score in exercise performance measure: vo2 max (ml o2/kg/min) at 26 weeks in the control groups was 2.8 |
The mean exercise performance measure: vo2 max (ml o2/kg/min) at 26 weeks in the intervention group was 0.8 lower (3.21 lower to 1.61 higher) |
Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias
The majority of the evidence included an indirect population (downgraded by one increment): downgraded if the ME/CFS diagnostic criteria used did not include PEM as a compulsory feature [original analysis]; percentage of participants with PEM unclear [PEM reanalysis – see Appendix G for additional details]
Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs
Studies included: Wearden 1998
From: Pharmacological interventions
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