Table 1, Summary of the protocol (PICO table) - Service delivery Models and settings for delivery of services

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Population	Adults with a diagnosis of depression according to DSM, ICD or similar criteria, or depressive symptoms as indicated by baseline depression scores on validated scales (and including those with subthreshold [just below threshold] depressive symptoms) For studies on relapse prevention: Adults whose depression has responded to treatment (in full or partial remission) according to DSM, ICD or similar criteria, or indicated by below clinical threshold depression symptom scores on validated scales
Intervention	Models for the coordination and delivery of services, including: Collaborative care (simple and complex) Stepped care Medication management Attached professional model Care co-ordination Integrated care pathways (including primary care liaison or shared care) Measurement-based care
Comparison	Treatment as usual Waitlist Any other service delivery model
Outcomes	Critical Depression symptomatology (mean endpoint score or change in depression score from baseline) at 6 and 12 months Response (usually defined as at least 50% improvement from the baseline score on a depression scale) at 6 and 12 months Remission (usually defined as a score below clinical threshold on a depression scale) at 6 and 12 months Relapse (number of people who returned to a depressive episode whilst in remission) at 6 and 12 months Important Antidepressant use at 6 and 12 months Discontinuation (due to any reason) at 6 and 12 months

: DSM: Diagnostic and Statistical Manual of Mental Disorders; ICD: International Classification of Diseases.

Service delivery Models and settings for delivery of services: Depression in adults: Evidence review A.

NICE Guideline, No. 222.

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