Table 12, Summary of included studies for primary care versus secondary care subgroup analysis for comparison 1a Cognitive and cognitive behavioural therapies individual + antidepressant versus antidepressant - Service delivery Models and settings for delivery of services

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Table 12Summary of included studies for primary care versus secondary care subgroup analysis for comparison 1a Cognitive and cognitive behavioural therapies individual + antidepressant versus antidepressant

Study	Population	Intervention	Comparison	Comments
Primary care (K=2, N=82)
Naeem 2011 RCT Pakistan	Primary care N=34 Baseline severity: More severe Mean age (years): 33.0 Sex (% female): 74 Ethnicity (% BME): NR	CBT individual (9 weekly or fortnightly sessions) + SSRI (paroxetine or fluoxetine 20mg/day)	SSRI (paroxetine or fluoxetine 20mg/day)	Treatment duration (weeks): 12 Outcomes (for primary versus secondary care subgroup analysis): Depression symptoms endpoint
Scott 1997 RCT UK	Primary care N=48 Baseline severity: More severe Mean age (years): 41.0 Sex (% female): 67 Ethnicity (% BME): NR	CBT individual (6x weekly 30-min sessions) + any antidepressant	Any antidepressant	Treatment duration (weeks): 7 Outcomes (for primary versus secondary care subgroup analysis): Depression symptoms endpoint
Secondary care (K=4, N=311)
Ashouri 2013 RCT Iran	Secondary care N=33 Baseline severity: More severe Mean age (years): 32.5 Sex (% female): 61 Ethnicity (% BME): NR	Third-wave cognitive therapy individual or CBT individual (number of sessions not reported) + any antidepressant	Any antidepressant	Treatment duration (weeks): NR Outcomes (for primary versus secondary care subgroup analysis): Depression symptoms endpoint
Hautzinger 1996^a RCT Germany	Secondary care N=76 Baseline severity: More severe Mean age (years): NR Sex (% female): NR Ethnicity (% BME): NR	CBT individual (24x 50-60 min sessions) + amitriptyline 150mg/day	Amitriptyline 150mg/day	Treatment duration (weeks): 8 Outcomes (for primary versus secondary care subgroup analysis): Depression symptoms endpoint
Hollon 1992^a RCT US	Secondary care N=82 Baseline severity: More severe Mean age (years): 32.6 Sex (% female): 80 Ethnicity (% BME): 9	CBT individual (maximum 20x 50-min weekly or fortnightly sessions) + imipramine 75-450mg/day	Imipramine 75-450mg/day	Treatment duration (weeks): 12 Outcomes (for primary versus secondary care subgroup analysis): Depression symptoms endpoint
Zu 2014^b RCT China	Secondary care N=120 Baseline severity: More severe Mean age (years): 38.3 Sex (% female): 49 Ethnicity (% BME): NR	CBT individual (20x 1-hour sessions) + any SSRI (dose NR, within recommended therapeutic dose ranges)	Any SSRI (dose NR, within recommended therapeutic dose ranges)	Treatment duration (weeks): 24 Outcomes (for primary versus secondary care subgroup analysis): Depression symptoms endpoint

a: Three-armed trial but where possible the demographics reported here are for only the two relevant arms.
b: Four-armed trial but where possible the demographics reported here are for only the two relevant arms.
: BME: black, minority, ethnic; CBT: cognitive behavioural therapy; K: number of studies; mg: milligrams; N: number of participants; NR: not reported; RCT: randomised controlled trial; SSRI: selective serotonin reuptake inhibitor.

From: Service delivery Models and settings for delivery of services

Cover of Service delivery Models and settings for delivery of services

Service delivery Models and settings for delivery of services: Depression in adults: Evidence review A.

NICE Guideline, No. 222.

London: National Institute for Health and Care Excellence (NICE); 2022 Jun.

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