Table 19, Summary of included studies for inpatient versus outpatient subgroup analysis for comparison 3b SSRIs versus tricyclic antidepressants (TCAs) - Service delivery Models and settings for delivery of services

Table 19Summary of included studies for inpatient versus outpatient subgroup analysis for comparison 3b SSRIs versus tricyclic antidepressants (TCAs)

Study	Population	Intervention	Comparison	Comments
Inpatient setting (K=11, N=1,347)
29060/299 RCT Europe	Inpatient N=217 Baseline severity: More severe Mean age (years): 40.4 Sex (% female): NR Ethnicity (% BME): NR	Paroxetine 20-50mg/day	Amitriptyline 100-250mg/day	Treatment duration (weeks): 8 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score
29060 07 001a RCT US	Inpatient N=26 Baseline severity: More severe Mean age (years): 42.3 Sex (% female): 65 Ethnicity (% BME): NR	Paroxetine 10-60mg/day	Amitriptyline (dose NR)	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score
Arminen 1992 RCT Finland	Inpatient N=57 Baseline severity: More severe Mean age (years): NR Sex (% female): 54 Ethnicity (% BME): NR	Paroxetine 20-40mg/day	Imipramine 100-200mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint
Danish University Antidepressant Group 1986 RCT Denmark	Inpatient N=114 Baseline severity: More severe Mean age (years): NR Sex (% female): 70 Ethnicity (% BME): NR	Citalopram 40mg/day	Clomipramine 150mg/day	Treatment duration (weeks): 5 Outcomes (for inpatient versus outpatient subgroup analysis): Remission
Danish University Antidepressant Group 1990 RCT Denmark	Inpatient N=120 Baseline severity: More severe Mean age (years): NR Sex (% female): 66 Ethnicity (% BME): NR	Paroxetine 30mg/day	Clomipramine 150mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Remission
Deushle 2003 RCT Germany	Inpatient N=126 Baseline severity: More severe Mean age (years): 54.1 Sex (% female): 67 Ethnicity (% BME): NR	Paroxetine 40mg/day	Amitriptyline 150mg/day	Treatment duration (weeks): 5 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score
Geretsegger 1995 RCT Austria & Germany	Inpatient N=91 Baseline severity: More severe Mean age (years): 71.2 Sex (% female): 86 Ethnicity (% BME): NR	Paroxetine 20-30mg/day	Amitriptyline 100-150mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Remission Response
Laakmann 1991 RCT Germany	Inpatient N=174 Baseline severity: More severe Mean age (years): NR Sex (% female): NR Ethnicity (% BME): NR	Fluoxetine (dose NR)	Amitriptyline 100-200mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint
Moller 1993 RCT Germany & Hungary	Inpatient N=222 Baseline severity: More severe Mean age (years): 47.1 Sex (% female): NR Ethnicity (% BME): NR	Paroxetine 30-50mg/day	Amitriptyline 150-250mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score Remission Response
Moller 1998 RCT Germany, Hungary, & Czech Republic	Inpatient N=160 Baseline severity: More severe Mean age (years): 48.6 Sex (% female): 70 Ethnicity (% BME): NR	Sertraline 50-150mg/day	Amitriptyline 75-150mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score Response
Staner 1995 RCT Belgium	Inpatient N=40 Baseline severity: More severe Mean age (years): 42.1 Sex (% female): 83 Ethnicity (% BME): NR	Paroxetine 30mg/day	Amitriptyline 150mg/day	Treatment duration (weeks): 5 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score Response
Outpatient setting (K=40, N=5,774)
Akhondzadeh 2003 RCT Iran	Outpatient N=48 Baseline severity: More severe Mean age (years): 35.8 Sex (% female): 40 Ethnicity (% BME): NR	Fluoxetine 60mg/day	Nortriptyline 150mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score
Beasley 1993b RCT US	Outpatient N=136 Baseline severity: More severe Mean age (years): 44.8 Sex (% female): 70 Ethnicity (% BME): 4	Fluoxetine 40-80mg/day	Amitriptyline 150-300mg/day	Treatment duration (weeks): 5 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score Remission Response
Bersani 1994 RCT Italy	Outpatient N=68 Baseline severity: More severe Mean age (years): 47.1 Sex (% female): 63 Ethnicity (% BME): NR	Sertraline 50-150mg/day	Amitriptyline 50-150mg/day	Treatment duration (weeks): 8 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score
Bhargava 2012 RCT India	Outpatient N=60 Baseline severity: More severe Mean age (years): 36.2 Sex (% female): 52 Ethnicity (% BME): NR	Sertraline 50-150mg/day	Imipramine 75-150mg/day	Treatment duration (weeks): 12 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score
Bremner 1984 RCT US	Outpatient N=40 Baseline severity: More severe Mean age (years): 42.6 Sex (% female): 51 Ethnicity (% BME): NR	Fluoxetine 60-80mg/day	Imipramine 125-300mg/day	Treatment duration (weeks): 5 Outcomes (for inpatient versus outpatient subgroup analysis): Response
Byerley 1988a RCT US	Outpatient N=66 Baseline severity: More severe Mean age (years): 39.3 Sex (% female): 68 Ethnicity (% BME): NR	Fluoxetine 40-80mg/day	Imipramine 150-300mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Response
Christiansen 1996 RCT Denmark	Outpatient N=144 Baseline severity: More severe Mean age (years): NR Sex (% female): NR Ethnicity (% BME): NR	Paroxetine 20-40mg/day	Amitriptyline 75-150mg/day	Treatment duration (weeks): 8 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Response
Cohn 1984b RCT US	Outpatient N=66 Baseline severity: More severe Mean age (years): 42 Sex (% female): NR Ethnicity (% BME): NR	Fluoxetine (dose NR)	Imipramine (dose NR)	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint
Cohn 1990b RCT US	Outpatient N=241 Baseline severity: More severe Mean age (years): 70.3 Sex (% female): 49 Ethnicity (% BME): NR	Sertraline 50-200mg/day	Amitriptyline 50-150mg/day	Treatment duration (weeks): 8 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score Response
De Ronchi 1998 RCT Italy	Outpatient N=65 Baseline severity: More severe Mean age (years): 68.9 Sex (% female): 72 Ethnicity (% BME): NR	Fluoxetine 20mg/day	Amitriptyline 50-100mg/day	Treatment duration (weeks): 10 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score Response
Demyttenaere 1998 RCT Belgium	Outpatient N=66 Baseline severity: More severe Mean age (years): 41.7 Sex (% female): 55 Ethnicity (% BME): NR	Fluoxetine 20mg/day	Amitriptyline 50mg/day	Treatment duration (weeks): 9 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score Response
Fabre 1991 RCT US	Outpatient N=205 Baseline severity: More severe Mean age (years): 37 Sex (% female): 57 Ethnicity (% BME): NR	Fluoxetine 40mg/day	Nortriptyline 100mg/day	Treatment duration (weeks): 5 Outcomes (for inpatient versus outpatient subgroup analysis): Response
Fabre 1992a RCT US	Outpatient N=80 Baseline severity: More severe Mean age (years): 35.4 Sex (% female): 61 Ethnicity (% BME): NR	Paroxetine 10-50mg/day	Imipramine 65-275mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score
Fawcett 1989 RCT US	Outpatient N=40 Baseline severity: More severe Mean age (years): 42.2 Sex (% female): 65 Ethnicity (% BME): NR	Fluoxetine 20-60mg/day	Amitriptyline 50-200mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score Remission Response
Feighner 1993a RCT US	Outpatient N=477 Baseline severity: More severe Mean age (years): 40.1 Sex (% female): 53 Ethnicity (% BME): NR	Paroxetine 10-50mg/day	Imipramine 65-275mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Remission
Forlenza 2001 RCT Brazil	Outpatient N=55 Baseline severity: More severe Mean age (years): 68.5 Sex (% female): 69 Ethnicity (% BME): NR	Sertraline 50mg/day	Imipramine 150mg/day	Treatment duration (weeks): 8 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score Remission Response
Freed 1999 RCT Australia	Outpatient N=375 Baseline severity: More severe Mean age (years): 48 Sex (% female): 65 Ethnicity (% BME): NR	Paroxetine 20mg/day	Amitriptyline 75mg/day	Treatment duration (weeks): 9 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score
Hashemi 2012 RCT Iran	Outpatient N=120 Baseline severity: More severe Mean age (years): 34.8 Sex (% female): 53 Ethnicity (% BME): NR	Fluoxetine maximum 60mg/day	Nortriptyline maximum 150mg/day	Treatment duration (weeks): 26 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score
Hutchinson 1992 RCT UK	Outpatient N=90 Baseline severity: More severe Mean age (years): 71.8 Sex (% female): 77 Ethnicity (% BME): NR	Paroxetine 30mg/day	Amitriptyline 100mg/day	Treatment duration (weeks): 26 Outcomes (for inpatient versus outpatient subgroup analysis): Remission Response
Kyle 1998 RCT UK	Outpatient N=365 Baseline severity: More severe Mean age (years): 73.8 Sex (% female): 73 Ethnicity (% BME): NR	Citalopram 20-40mg/day	Amitriptyline 50-100mg/day	Treatment duration (weeks): 8 Outcomes (for inpatient versus outpatient subgroup analysis): Remission
Laakmann 1988 RCT Germany	Outpatient N=128 Baseline severity: More severe Mean age (years): NR Sex (% female): 72 Ethnicity (% BME): NR	Fluoxetine 20-60mg/day	Amitriptyline 50-150mg/day	Treatment duration (weeks): 5 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Response
Marchesi 1998 RCT Italy	Outpatient N=142 Baseline severity: More severe Mean age (years): 43.6 Sex (% female): 74 Ethnicity (% BME): NR	Fluoxetine 20mg/day	Amitriptyline 75-225mg/day	Treatment duration (weeks): 10 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score Response
MDF/29060/III/07 0/88/MC RCT Europe	Outpatient N=62 Baseline severity: More severe Mean age (years): 73 Sex (% female): NR Ethnicity (% BME): NR	Paroxetine 20-30mg/day	Clomipramine 60-75mg/day	Treatment duration (weeks): 5 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score Remission Response
Moller 2000 RCT Germany	Outpatient N=240 Baseline severity: More severe Mean age (years): 47.9 Sex (% female): 67 Ethnicity (% BME): NR	Sertraline 50-100mg/day	Amitriptyline 75-150mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score Response
Moon 1994 RCT UK	Outpatient N=106 Baseline severity: More severe Mean age (years): 43.7 Sex (% female): 52 Ethnicity (% BME): NR	Sertraline 50-150mg/day	Clomipramine 50-150mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Response
Moon 1996 RCT UK	Outpatient N=138 Baseline severity: More severe Mean age (years): 43.7 Sex (% female): 71 Ethnicity (% BME): NR	Paroxetine 20-30mg/day	Lofepramine 70-210mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Remission Response
Ontiveros Sanchez 1998 RCT South America	Outpatient N=42 Baseline severity: More severe Mean age (years): 37.6 Sex (% female): 53 Ethnicity (% BME): NR	Fluoxetine 20mg/day	Amitriptyline 150-250mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Response
PAR 29060/281 RCT Europe	Outpatient N=162 Baseline severity: More severe Mean age (years): 38.8 Sex (% female): 77 Ethnicity (% BME): NR	Paroxetine 30mg/day	Amitriptyline 75-150mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint
PAR MDUK 032 RCT Country NR	Outpatient N=59 Baseline severity: More severe Mean age (years): 44.4 Sex (% female): NR Ethnicity (% BME): NR	Paroxetine 20-30mg/day	Amitriptyline 100-150mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint
Peselow 1989aa RCT US	Outpatient N=66 Baseline severity: More severe Mean age (years): 45.9 Sex (% female): 35 Ethnicity (% BME): NR	Paroxetine 10-50mg/day	Imipramine 65-275mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Response
Peselow 1989ba RCT US	Outpatient N=80 Baseline severity: More severe Mean age (years): NR Sex (% female): NR Ethnicity (% BME): NR	Paroxetine 20-50mg/day	Imipramine 65-275mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Response
Peters 1990 RCT Germany	Outpatient N=102 Baseline severity: More severe Mean age (years): 44.5 Sex (% female): 63 Ethnicity (% BME): NR	Fluoxetine 20mg/day	Amitriptyline 100mg/day	Treatment duration (weeks): 5 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Response
Preskorn 1991 RCT US	Outpatient N=61 Baseline severity: More severe Mean age (years): NR Sex (% female): NR Ethnicity (% BME): 2	Fluoxetine 20-60mg/day	Amitriptyline 50-200mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score
Reimherr 1990a RCT US & Canada	Outpatient N=298 Baseline severity: More severe Mean age (years): 38.4 Sex (% female): 55 Ethnicity (% BME): 10	Sertraline 20-200mg/day	Amitriptyline 50-150mg/day	Treatment duration (weeks): 8 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score Response
Ropert 1989 RCT France	Outpatient N=143 Baseline severity: More severe Mean age (years): 43.8 Sex (% female): 64 Ethnicity (% BME): NR	Fluoxetine 20mg/day	Clomipramine 75mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score
Rosenberg 1994 RCT Denmark, Norway, Sweden & Finland	Outpatient N=472 Baseline severity: More severe Mean age (years): 47.6 Sex (% female): 69 Ethnicity (% BME): NR	Citalopram 10-30mg/day or 20-60mg/day	Imipramine 50-150mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Response
SER 315 (FDA)^a RCT Europe	Outpatient N=162 Baseline severity: More severe Mean age (years): 42.4 Sex (% female): 69 Ethnicity (% BME): NR	Sertraline 50-200mg/day	Amitriptyline 50-200mg/day	Treatment duration (weeks): 8 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score
Serrano-Blanco 2006 RCT Spain	Outpatient N=103 Baseline severity: More severe Mean age (years): 43.5 Sex (% female): 73 Ethnicity (% BME): NR	Fluoxetine 10-40mg/day	Imipramine 25-125mg/day	Treatment duration (weeks): 24 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score
Stark 1985a RCT US	Outpatient N=371 Baseline severity: More severe Mean age (years): 41.0 Sex (% female): 69 Ethnicity (% BME): NR	Fluoxetine 60-80mg/day	Imipramine 100-300mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms change score Response
Suleman 1997 RCT Zimbabwe	Outpatient N=30 Baseline severity: More severe Mean age (years): NR Sex (% female): NR Ethnicity (% BME): NR	Fluoxetine 20mg/day	Amitriptyline 100mg/day	Treatment duration (weeks): 6 Outcomes (for inpatient versus outpatient subgroup analysis): Depression symptoms endpoint Depression symptoms change score

Study

Population

Intervention

Comparison

Comments

Inpatient setting (K=11, N=1,347)

29060/299

RCT

Europe

Inpatient

N=217

Baseline severity: More severe

Mean age (years): 40.4

Sex (% female): NR

Ethnicity (% BME): NR

Paroxetine 20-50mg/day

Amitriptyline 100-250mg/day

Treatment duration (weeks): 8

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score

29060 07 001a

RCT

Inpatient

N=26

Baseline severity: More severe

Mean age (years): 42.3

Sex (% female): 65

Ethnicity (% BME): NR

Paroxetine 10-60mg/day

Amitriptyline (dose NR)

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score

Arminen 1992

RCT

Finland

Inpatient

N=57

Baseline severity: More severe

Mean age (years): NR

Sex (% female): 54

Ethnicity (% BME): NR

Paroxetine 20-40mg/day

Imipramine 100-200mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint

Danish University Antidepressant Group 1986

RCT

Denmark

Inpatient

N=114

Baseline severity: More severe

Mean age (years): NR

Sex (% female): 70

Ethnicity (% BME): NR

Citalopram 40mg/day

Clomipramine 150mg/day

Treatment duration (weeks): 5

Outcomes (for inpatient versus outpatient subgroup analysis):

Remission

Danish University Antidepressant Group 1990

RCT

Denmark

Inpatient

N=120

Baseline severity: More severe

Mean age (years): NR

Sex (% female): 66

Ethnicity (% BME): NR

Paroxetine 30mg/day

Clomipramine 150mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Remission

Deushle 2003

RCT

Germany

Inpatient

N=126

Baseline severity: More severe

Mean age (years): 54.1

Sex (% female): 67

Ethnicity (% BME): NR

Paroxetine 40mg/day

Amitriptyline 150mg/day

Treatment duration (weeks): 5

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score

Geretsegger 1995

RCT

Austria & Germany

Inpatient

N=91

Baseline severity: More severe

Mean age (years): 71.2

Sex (% female): 86

Ethnicity (% BME): NR

Paroxetine 20-30mg/day

Amitriptyline 100-150mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Remission
Response

Laakmann 1991

RCT

Germany

Inpatient

N=174

Baseline severity: More severe

Mean age (years): NR

Sex (% female): NR

Ethnicity (% BME): NR

Fluoxetine (dose NR)

Amitriptyline 100-200mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint

Moller 1993

RCT

Germany & Hungary

Inpatient

N=222

Baseline severity: More severe

Mean age (years): 47.1

Sex (% female): NR

Ethnicity (% BME): NR

Paroxetine 30-50mg/day

Amitriptyline 150-250mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score
Remission
Response

Moller 1998

RCT

Germany, Hungary, & Czech Republic

Inpatient

N=160

Baseline severity: More severe

Mean age (years): 48.6

Sex (% female): 70

Ethnicity (% BME): NR

Sertraline 50-150mg/day

Amitriptyline 75-150mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score
Response

Staner 1995

RCT

Belgium

Inpatient

N=40

Baseline severity: More severe

Mean age (years): 42.1

Sex (% female): 83

Ethnicity (% BME): NR

Paroxetine 30mg/day

Amitriptyline 150mg/day

Treatment duration (weeks): 5

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score
Response

Outpatient setting (K=40, N=5,774)

Akhondzadeh 2003

RCT

Iran

Outpatient

N=48

Baseline severity: More severe

Mean age (years): 35.8

Sex (% female): 40

Ethnicity (% BME): NR

Fluoxetine 60mg/day

Nortriptyline 150mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score

Beasley 1993b

RCT

Outpatient

N=136

Baseline severity: More severe

Mean age (years): 44.8

Sex (% female): 70

Ethnicity (% BME): 4

Fluoxetine 40-80mg/day

Amitriptyline 150-300mg/day

Treatment duration (weeks): 5

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score
Remission
Response

Bersani 1994

RCT

Italy

Outpatient

N=68

Baseline severity: More severe

Mean age (years): 47.1

Sex (% female): 63

Ethnicity (% BME): NR

Sertraline 50-150mg/day

Amitriptyline 50-150mg/day

Treatment duration (weeks): 8

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score

Bhargava 2012

RCT

India

Outpatient

N=60

Baseline severity: More severe

Mean age (years): 36.2

Sex (% female): 52

Ethnicity (% BME): NR

Sertraline 50-150mg/day

Imipramine 75-150mg/day

Treatment duration (weeks): 12

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score

Bremner 1984

RCT

Outpatient

N=40

Baseline severity: More severe

Mean age (years): 42.6

Sex (% female): 51

Ethnicity (% BME): NR

Fluoxetine 60-80mg/day

Imipramine 125-300mg/day

Treatment duration (weeks): 5

Outcomes (for inpatient versus outpatient subgroup analysis):

Response

Byerley 1988a

RCT

Outpatient

N=66

Baseline severity: More severe

Mean age (years): 39.3

Sex (% female): 68

Ethnicity (% BME): NR

Fluoxetine 40-80mg/day

Imipramine 150-300mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Response

Christiansen 1996

RCT

Denmark

Outpatient

N=144

Baseline severity: More severe

Mean age (years): NR

Sex (% female): NR

Ethnicity (% BME): NR

Paroxetine 20-40mg/day

Amitriptyline 75-150mg/day

Treatment duration (weeks): 8

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Response

Cohn 1984b

RCT

Outpatient

N=66

Baseline severity: More severe

Mean age (years): 42

Sex (% female): NR

Ethnicity (% BME): NR

Fluoxetine (dose NR)

Imipramine (dose NR)

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint

Cohn 1990b

RCT

Outpatient N=241

Baseline severity: More severe

Mean age (years): 70.3

Sex (% female): 49

Ethnicity (% BME): NR

Sertraline 50-200mg/day

Amitriptyline 50-150mg/day

Treatment duration (weeks): 8

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score
Response

De Ronchi 1998

RCT

Italy

Outpatient

N=65

Baseline severity: More severe

Mean age (years): 68.9

Sex (% female): 72

Ethnicity (% BME): NR

Fluoxetine 20mg/day

Amitriptyline 50-100mg/day

Treatment duration (weeks): 10

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score
Response

Demyttenaere 1998

RCT

Belgium

Outpatient

N=66

Baseline severity: More severe

Mean age (years): 41.7

Sex (% female): 55

Ethnicity (% BME): NR

Fluoxetine 20mg/day

Amitriptyline 50mg/day

Treatment duration (weeks): 9

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score
Response

Fabre 1991

RCT

Outpatient

N=205

Baseline severity: More severe

Mean age (years): 37

Sex (% female): 57

Ethnicity (% BME): NR

Fluoxetine 40mg/day

Nortriptyline 100mg/day

Treatment duration (weeks): 5

Outcomes (for inpatient versus outpatient subgroup analysis):

Response

Fabre 1992a

RCT

Outpatient

N=80

Baseline severity: More severe

Mean age (years): 35.4

Sex (% female): 61

Ethnicity (% BME): NR

Paroxetine 10-50mg/day

Imipramine 65-275mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score

Fawcett 1989

RCT

Outpatient

N=40

Baseline severity: More severe

Mean age (years): 42.2

Sex (% female): 65

Ethnicity (% BME): NR

Fluoxetine 20-60mg/day

Amitriptyline 50-200mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score
Remission
Response

Feighner 1993a

RCT

Outpatient

N=477

Baseline severity: More severe

Mean age (years): 40.1

Sex (% female): 53

Ethnicity (% BME): NR

Paroxetine 10-50mg/day

Imipramine 65-275mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Remission

Forlenza 2001

RCT

Brazil

Outpatient

N=55

Baseline severity: More severe

Mean age (years): 68.5

Sex (% female): 69

Ethnicity (% BME): NR

Sertraline 50mg/day

Imipramine 150mg/day

Treatment duration (weeks): 8

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score
Remission
Response

Freed 1999

RCT

Australia

Outpatient

N=375

Baseline severity: More severe

Mean age (years): 48

Sex (% female): 65

Ethnicity (% BME): NR

Paroxetine 20mg/day

Amitriptyline 75mg/day

Treatment duration (weeks): 9

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score

Hashemi 2012

RCT

Iran

Outpatient

N=120

Baseline severity: More severe

Mean age (years): 34.8

Sex (% female): 53

Ethnicity (% BME): NR

Fluoxetine maximum 60mg/day

Nortriptyline maximum 150mg/day

Treatment duration (weeks): 26

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score

Hutchinson 1992

RCT

Outpatient

N=90

Baseline severity: More severe

Mean age (years): 71.8

Sex (% female): 77

Ethnicity (% BME): NR

Paroxetine 30mg/day

Amitriptyline 100mg/day

Treatment duration (weeks): 26

Outcomes (for inpatient versus outpatient subgroup analysis):

Remission
Response

Kyle 1998

RCT

Outpatient

N=365

Baseline severity: More severe

Mean age (years): 73.8

Sex (% female): 73

Ethnicity (% BME): NR

Citalopram 20-40mg/day

Amitriptyline 50-100mg/day

Treatment duration (weeks): 8

Outcomes (for inpatient versus outpatient subgroup analysis):

Remission

Laakmann 1988

RCT

Germany

Outpatient

N=128

Baseline severity: More severe

Mean age (years): NR

Sex (% female): 72

Ethnicity (% BME): NR

Fluoxetine 20-60mg/day

Amitriptyline 50-150mg/day

Treatment duration (weeks): 5

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Response

Marchesi 1998

RCT

Italy

Outpatient

N=142

Baseline severity: More severe

Mean age (years): 43.6

Sex (% female): 74

Ethnicity (% BME): NR

Fluoxetine 20mg/day

Amitriptyline 75-225mg/day

Treatment duration (weeks): 10

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score
Response

MDF/29060/III/07 0/88/MC

RCT

Europe

Outpatient

N=62

Baseline severity: More severe

Mean age (years): 73

Sex (% female): NR

Ethnicity (% BME): NR

Paroxetine 20-30mg/day

Clomipramine 60-75mg/day

Treatment duration (weeks): 5

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score
Remission
Response

Moller 2000

RCT

Germany

Outpatient

N=240

Baseline severity: More severe

Mean age (years): 47.9

Sex (% female): 67

Ethnicity (% BME): NR

Sertraline 50-100mg/day

Amitriptyline 75-150mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score
Response

Moon 1994

RCT

Outpatient

N=106

Baseline severity: More severe

Mean age (years): 43.7

Sex (% female): 52

Ethnicity (% BME): NR

Sertraline 50-150mg/day

Clomipramine 50-150mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Response

Moon 1996

RCT

Outpatient

N=138

Baseline severity: More severe

Mean age (years): 43.7

Sex (% female): 71

Ethnicity (% BME): NR

Paroxetine 20-30mg/day

Lofepramine 70-210mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Remission
Response

Ontiveros Sanchez 1998

RCT

South America

Outpatient

N=42

Baseline severity: More severe

Mean age (years): 37.6

Sex (% female): 53

Ethnicity (% BME): NR

Fluoxetine 20mg/day

Amitriptyline 150-250mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Response

PAR 29060/281

RCT

Europe

Outpatient

N=162

Baseline severity: More severe

Mean age (years): 38.8

Sex (% female): 77

Ethnicity (% BME): NR

Paroxetine 30mg/day

Amitriptyline 75-150mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint

PAR MDUK 032

RCT

Country NR

Outpatient

N=59

Baseline severity: More severe

Mean age (years): 44.4

Sex (% female): NR

Ethnicity (% BME): NR

Paroxetine 20-30mg/day

Amitriptyline 100-150mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint

Peselow 1989aa

RCT

Outpatient

N=66

Baseline severity: More severe

Mean age (years): 45.9

Sex (% female): 35

Ethnicity (% BME): NR

Paroxetine 10-50mg/day

Imipramine 65-275mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Response

Peselow 1989ba

RCT

Outpatient

N=80

Baseline severity: More severe

Mean age (years): NR

Sex (% female): NR

Ethnicity (% BME): NR

Paroxetine 20-50mg/day

Imipramine 65-275mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Response

Peters 1990

RCT

Germany

Outpatient

N=102

Baseline severity: More severe

Mean age (years): 44.5

Sex (% female): 63

Ethnicity (% BME): NR

Fluoxetine 20mg/day

Amitriptyline 100mg/day

Treatment duration (weeks): 5

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Response

Preskorn 1991

RCT

Outpatient

N=61

Baseline severity: More severe

Mean age (years): NR

Sex (% female): NR

Ethnicity (% BME): 2

Fluoxetine 20-60mg/day

Amitriptyline 50-200mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score

Reimherr 1990a

RCT

US & Canada

Outpatient

N=298

Baseline severity: More severe

Mean age (years): 38.4

Sex (% female): 55

Ethnicity (% BME): 10

Sertraline 20-200mg/day

Amitriptyline 50-150mg/day

Treatment duration (weeks): 8

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score
Response

Ropert 1989

RCT

France

Outpatient

N=143

Baseline severity: More severe

Mean age (years): 43.8

Sex (% female): 64

Ethnicity (% BME): NR

Fluoxetine 20mg/day

Clomipramine 75mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score

Rosenberg 1994

RCT

Denmark, Norway, Sweden & Finland

Outpatient

N=472

Baseline severity: More severe

Mean age (years): 47.6

Sex (% female): 69

Ethnicity (% BME): NR

Citalopram 10-30mg/day or 20-60mg/day

Imipramine 50-150mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Response

SER 315 (FDA)^a

RCT

Europe

Outpatient

N=162

Baseline severity: More severe

Mean age (years): 42.4

Sex (% female): 69

Ethnicity (% BME): NR

Sertraline 50-200mg/day

Amitriptyline 50-200mg/day

Treatment duration (weeks): 8

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score

Serrano-Blanco 2006

RCT

Spain

Outpatient

N=103

Baseline severity: More severe

Mean age (years): 43.5

Sex (% female): 73

Ethnicity (% BME): NR

Fluoxetine 10-40mg/day

Imipramine 25-125mg/day

Treatment duration (weeks): 24

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score

Stark 1985a

RCT

Outpatient

N=371

Baseline severity: More severe

Mean age (years): 41.0

Sex (% female): 69

Ethnicity (% BME): NR

Fluoxetine 60-80mg/day

Imipramine 100-300mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms change score
Response

Suleman 1997

RCT

Zimbabwe

Outpatient

N=30

Baseline severity: More severe

Mean age (years): NR

Sex (% female): NR

Ethnicity (% BME): NR

Fluoxetine 20mg/day

Amitriptyline 100mg/day

Treatment duration (weeks): 6

Outcomes (for inpatient versus outpatient subgroup analysis):

Depression symptoms endpoint
Depression symptoms change score

a: Three-armed trial but where possible the demographics reported here are for only the two relevant arms.
: BME: black, minority, ethnic; mg: milligrams; N: number of participants; NR: not reported; RCT: randomised controlled trial.

From: Service delivery Models and settings for delivery of services

Cover of Service delivery Models and settings for delivery of services

Service delivery Models and settings for delivery of services: Depression in adults: Evidence review A.

NICE Guideline, No. 222.

London: National Institute for Health and Care Excellence (NICE); 2022 Jun.

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