| Study | Population | Intervention | Comparison | Comments |
|---|---|---|---|---|
| Inpatient setting (K=2, N=425) | ||||
|
Richou 1995 RCT France |
Inpatient N=174 Baseline severity: More severe Mean age (years): 50.7 Sex (% female): 67 Ethnicity (% BME): NR | Mirtazapine 20-80mg/day | Clomipramine 50-200mg/day |
Treatment duration (weeks): 6 Outcome (for inpatient versus outpatient subgroup analysis):
|
|
Zivkov 1995 RCT Former Yugoslavia |
Inpatient N=251 Baseline severity: More severe Mean age (years): 46.9 Sex (% female): 78 Ethnicity (% BME): NR | Mirtazapine 20-60mg/day | Amitriptyline 75-225mg/day |
Treatment duration (weeks): 6 Outcome (for inpatient versus outpatient subgroup analysis):
|
| Outpatient setting (K=4, N=387) | ||||
|
Bremner 1995a RCT US |
Outpatient N=100 Baseline severity: More severe Mean age (years): 39.0 Sex (% female): 67 Ethnicity (% BME): NR | Mirtazapine 5-35mg/day | Amitriptyline 40-280mg/day |
Treatment duration (weeks): 6 Outcome (for inpatient versus outpatient subgroup analysis):
|
|
MIR 003-020 (FDA)a RCT US |
Outpatient N=87 Baseline severity: More severe Mean age (years): 43.5 Sex (% female): 45 Ethnicity (% BME): NR | Mirtazapine 5-35mg/day | Amitriptyline 40-280mg/day |
Treatment duration (weeks): 6 Outcome (for inpatient versus outpatient subgroup analysis):
|
|
MIR 003-021 (FDA)a RCT US |
Outpatient N=100 Baseline severity: More severe Mean age (years): 44.5 Sex (% female): 55 Ethnicity (% BME): NR | Mirtazapine 5-35mg/day | Amitriptyline 40-280mg/day |
Treatment duration (weeks): 6 Outcome (for inpatient versus outpatient subgroup analysis):
|
|
Smith 1990a RCT US |
Outpatient N=100 Baseline severity: More severe Mean age (years): NR Sex (% female): NR Ethnicity (% BME): NR | Mirtazapine 10-35mg/day | Amitriptyline 80-280mg/day |
Treatment duration (weeks): 6 Outcome (for inpatient versus outpatient subgroup analysis):
|
Three-armed trial but where possible the demographics reported here are for only the two relevant arms.
BME: black, minority, ethnic; mg: milligrams; N: number of participants; NR: not reported; RCT: randomised controlled trial.
From: Service delivery Models and settings for delivery of services
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