Table 2, Summary of included studies for Comparison 1: Collaborative care (simple or complex) versus standard care/enhanced standard care - Service delivery Models and settings for delivery of services

Table 2Summary of included studies for Comparison 1: Collaborative care (simple or complex) versus standard care/enhanced standard care

Study	Population	Intervention	Comparison	Comments
Aragones 2012 RCT Spain	N=360 Baseline severity: More severe Mean age (years): 47.6 Sex (% female): 79 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 9	Standard care	Duration of programme contact (in months): NR Outcomes: Depression symptomatology at 6 months Depression symptomatology at 12 months Response at 6 months Response at 12 months Remission at 6 months Remission at 12 months Antidepressant use at 6 months Antidepressant use at 12 months Discontinuation at 6 months Discontinuation at 12 months
Araya 2003 RCT Chile	N=240 Baseline severity: More severe Mean age (years): 42.6 Sex (% female): 100 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 7	Standard care	Duration of programme contact (in months): 3 Outcomes: Response at 6 months Remission at 6 months Antidepressant use at 6 months Discontinuation at 6 months
Berghofer 2012 RCT Germany	N=63 Baseline severity: More severe Mean age (years): 49.7 Sex (% female): 73 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 10	Standard care	Duration of programme contact (in months): 6 Outcomes: Response at 6 months Response at 12 months
Bjorkelund 2018 RCT Sweden	N=385 Baseline severity: Less severe Mean age (years): 41.2 Sex (% female): 71 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 9	Standard care	Duration of programme contact (in months): 3 Outcomes: Remission at 6 months Antidepressant use at 6 months Discontinuation at 6 months
Bosanquet 2017 RCT UK	N=485 Baseline severity: Less severe Mean age (years): 72.2 Sex (% female): 62 Ethnicity (% BME): 2	Simple collaborative care Collaborative care component score: 8	Enhanced standard care	Duration of programme contact (in months): 2 Outcomes: Depression symptomatology at 12 months Antidepressant use at 12 months Discontinuation at 12 months
Bruce 2004 RCT US	N=598 Baseline severity: More severe Mean age (years): NR (>60) Sex (% female): 72 Ethnicity (% BME): 28	Simple collaborative care Collaborative care component score: 11.5	Enhanced standard care	Duration of programme contact (in months): 12 Outcomes: Depression symptomatology at 12 months Response at 12 months Remission at 12 months Antidepressant use at 12 months Discontinuation at 12 months
Buszewicz 2016 RCT UK	N=558 Baseline severity: More severe Mean age (years): 48.4 Sex (% female): 75 Ethnicity (% BME): 12	Simple collaborative care Collaborative care component score: 11	Standard care	Duration of programme contact (in months): 24 Outcomes: Depression symptomatology at 6 months Depression symptomatology at 12 months Discontinuation at 6 months Discontinuation at 12 months
Capoccia 2004 RCT US	N=74 Baseline severity: NR Mean age (years): 38.7 Sex (% female): 77 Ethnicity (% BME): 22	Simple collaborative care Collaborative care component score: 8	Standard care	Duration of programme contact (in months): 12 Outcomes: Antidepressant use at 12 months Discontinuation at 12 months
Chen 2015 RCT China	N=326 Baseline severity: More severe Mean age (years): NR (>60) Sex (% female): 63 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 12	Enhanced standard care	Duration of programme contact (in months): 4 Outcomes: Depression symptomatology at 6 months Depression symptomatology at 12 months Response at 6 months Response at 12 months Remission at 6 months Remission at 12 months Discontinuation at 6 months Discontinuation at 12 months
Curth 2020 RCT Denmark	N=325 Baseline severity: Less severe Mean age (years): 39 Sex (% female): 67 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 11	Standard care	Duration of programme contact (in months): 4 Outcomes: Depression symptomatology at 6 months Discontinuation at 6 months
Dobscha 2006 RCT US	N=375 Baseline severity: Less severe Mean age (years): 56.8 Sex (% female): 7 Ethnicity (% BME): 3	Simple collaborative care Collaborative care component score: 9	Enhanced standard care	Duration of programme contact (in months): 12 Outcomes: Antidepressant use at 12 months Discontinuation at 12 months
Ell 2007 RCT US	N=311 Baseline severity: NR Mean age (years): NR (>60) Sex (% female): 72 Ethnicity (% BME): 27	Simple collaborative care Collaborative care component score: 10.5	Enhanced standard care	Duration of programme contact (in months): 12 Outcomes: Response at 12 months Remission at 12 months Antidepressant use at 12 months Discontinuation at 12 months
Finley 2003 RCT US	N=125 Baseline severity: NR Mean age (years): 54.3 Sex (% female): 85 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 6.5	Standard care	Duration of programme contact (in months): 6 Outcomes: Antidepressant use at 6 months Discontinuation at 6 months
Fortney 2007 RCT US	N=395 Baseline severity: More severe Mean age (years): 59.2 Sex (% female): 8 Ethnicity (% BME): 25	Complex collaborative care Collaborative care component score: 13	Enhanced standard care	Duration of programme contact (in months): 12 Outcomes: Antidepressant use at 12 months Discontinuation at 12 months
Gensichen 2009 RCT Germany	N=626 Baseline severity: More severe Mean age (years): 51.1 Sex (% female): 76 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 7	Standard care	Duration of programme contact (in months): 12 Outcomes: Depression symptomatology at 12 months Response at 12 months Remission at 12 months Antidepressant use at 12 months Discontinuation at 12 months
Gilbody 2017/Lewis 2017 RCT UK	N=705 Baseline severity: Less severe Mean age (years): 77.3 Sex (% female): 58 Ethnicity (% BME): 1	Simple collaborative care Collaborative care component score: 10	Standard care	Duration of programme contact (in months): 2 Outcomes: Depression symptomatology at 12 months Antidepressant use at 12 months Discontinuation at 12 months
Harter 2018 RCT Germany	N=779 Baseline severity: Less severe Mean age (years): 42.9 Sex (% female): 73 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 11	Standard care	Duration of programme contact (in months): NR Outcomes: Depression symptomatology at 6 months Depression symptomatology at 12 months Response at 12 months Remission at 12 months Discontinuation at 6 months Discontinuation at 12 months
Holzel 2018 RCT Germany	N=248 Baseline severity: Less severe Mean age (years): 71.4 Sex (% female): 77 Ethnicity (% BME): NR	Complex collaborative care Collaborative care component score: 14	Standard care	Duration of programme contact (in months): 12 Outcomes: Depression symptomatology at 12 months Response at 12 months Remission at 12 months
Huang 2018 RCT China	N=280 Baseline severity: More severe Mean age (years): 47.4 Sex (% female): 85 Ethnicity (% BME): 100	Simple collaborative care Collaborative care component score: 10	Standard care	Duration of programme contact (in months): 6 Outcomes: Depression symptomatology at 6 months Discontinuation at 6 months
Huijbregts 2013 RCT Netherlands	N=150 Baseline severity: Less severe Mean age (years): 48.7 Sex (% female): 73 Ethnicity (% BME): 29	Complex collaborative care Collaborative care component score: 13	Standard care	Duration of programme contact (in months): 12 Outcomes: Response at 6 months Response at 12 months Remission at 6 months Remission at 12 months Discontinuation at 6 months Discontinuation at 12 months
Jarjoura 2004 RCT US	N=61 Baseline severity: More severe Mean age (years): 45.5 Sex (% female): 69 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 6	Enhanced standard care	Duration of programme contact (in months): NR Outcomes: Antidepressant use at 12 months
Jeong 2013 RCT Korea	N=57 Baseline severity: More severe Mean age (years): NR (>60) Sex (% female): 58 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 7	Standard care	Duration of programme contact (in months): 6 Outcomes: Remission at 6 months Antidepressant use at 6 months Discontinuation at 6 months
Katon 1999 RCT US	N=228 Baseline severity: NR Mean age (years): 47 Sex (% female): 75 Ethnicity (% BME): 20	Simple collaborative care Collaborative care component score: 6	Standard care	Duration of programme contact (in months): 3 Outcomes: Remission at 6 months Antidepressant use at 6 months
Katzelnick 2000 RCT US	N=407 Baseline severity: More severe Mean age (years): 45.5 Sex (% female): 77 Ethnicity (% BME): 21	Simple collaborative care Collaborative care component score: 9	Standard care	Duration of programme contact (in months): 7 Outcomes: Response at 12 months Remission at 12 months Discontinuation at 12 months
Landis 2007 RCT US	N=45 Baseline severity: More severe Mean age (years): 39.7 Sex (% female): 96 Ethnicity (% BME): 28	Simple collaborative care Collaborative care component score: 9	Enhanced standard care	Duration of programme contact (in months): 6 Outcome: Depression symptomatology at 6 months
Ludman 2007 RCT US	N=52 Baseline severity: NR Mean age (years): 50.3 Sex (% female): 69 Ethnicity (% BME): 13	Simple collaborative care Collaborative care component score: 9	Standard care	Duration of programme contact (in months): NR Outcomes: Remission at 12 months Antidepressant use at 12 months Discontinuation at 12 months
Morris 2016 RCT UK	N=187 Baseline severity: More severe Mean age (years): 46.5 Sex (% female): 61 Ethnicity (% BME): NR	Complex collaborative care Collaborative care component score: 14	Standard care	Duration of programme contact (in months): 12 Outcomes: Depression symptomatology at 12 months Response at 12 months Remission at 12 months Discontinuation at 12 months
Ng 2020 RCT Singapore	N=274 Baseline severity: Less severe Mean age (years): 73.5 Sex (% female): 56 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 9	Standard care	Duration of programme contact (in months): 6 Outcomes: Depression symptomatology at 6 months Depression symptomatology at 12 months Response at 6 months Response at 12 months Remission at 6 months Remission at 12 months Discontinuation at 6 months Discontinuation at 12 months
Oladeji 2015 RCT Nigeria	N=234 Baseline severity: Less severe Mean age (years): 43.2 Sex (% female): 80 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 12	Enhanced standard care	Duration of programme contact (in months): 6 Outcomes: Depression symptomatology at 6 months Discontinuation at 6 months
Richards 2013/2016 RCT UK	N=581 Baseline severity: More severe Mean age (years): 44.8 Sex (% female): 72 Ethnicity (% BME): 15	Simple collaborative care Collaborative care component score: 12	Standard care	Duration of programme contact (in months): 3 Outcomes: Depression symptomatology at 12 months Response at 12 months Remission at 12 months Antidepressant use at 12 months Discontinuation at 12 months
Simon 2004 (CM) RCT US	N=402 Baseline severity: Less severe Mean age (years): 44.5 Sex (% female): 75 Ethnicity (% BME): 20	Simple collaborative care Collaborative care component score: 9	Standard care	Duration of programme contact (in months): 5 Outcomes: Antidepressant use at 6 months Discontinuation at 6 months
Simon 2004 (CM + psych) RCT US	N=393 Baseline severity: Less severe Mean age (years): 44.4 Sex (% female): 76 Ethnicity (% BME): 23	Complex collaborative care Collaborative care component score:13	Standard care	Duration of programme contact (in months): 5 Outcomes: Antidepressant use at 6 months Discontinuation at 6 months
Simon 2006 RCT US	N=207 Baseline severity: Less severe Mean age (years): 43 Sex (% female): 65 Ethnicity (% BME): 11	Simple collaborative care Collaborative care component score: 9	Standard care	Duration of programme contact (in months): 3 Outcomes: Antidepressant use at 6 months Discontinuation at 6 months
Smit 2006 RCT Netherlands	N=267 Baseline severity: Less severe Mean age (years): 42.8 Sex (% female): 64 Ethnicity (% BME): NR	Simple collaborative care Collaborative care component score: 9.5	Standard care	Duration of programme contact (in months): 6 Outcomes: Remission at 6 months Antidepressant use at 6 months Discontinuation at 6 months
Swindle 2003 RCT US	N=268 Baseline severity: Less severe Mean age (years): 56.3 Sex (% female): 3 Ethnicity (% BME): 15	Simple collaborative care Collaborative care component score: 8	Enhanced standard care	Duration of programme contact (in months): 2 Outcomes: Depression symptomatology at 12 months Discontinuation at 12 months
Unutzer 2002/Arean 2005 RCT US	N=1901 Baseline severity: NR Mean age (years): 71.2 Sex (% female): 65 Ethnicity (% BME): 23	Complex collaborative care Collaborative care component score: 14.5	Standard care	Duration of programme contact (in months): 12 Outcomes: Antidepressant use at 6 months Antidepressant use at 12 months Discontinuation at 6 months Discontinuation at 12 months
Wells 2000 RCT US	N=1356 Baseline severity: NR Mean age (years): 43.7 Sex (% female): 71 Ethnicity (% BME): 43	Simple collaborative care Collaborative care component score: 8.5	Standard care	Duration of programme contact (in months): 12 Outcomes: Remission at 6 months Remission at 12 months Discontinuation at 6 months Discontinuation at 12 months
Yeung 2010 RCT US	N=100 Baseline severity: More severe Mean age (years): 49 Sex (% female): 68 Ethnicity (% BME): 100	Simple collaborative care Collaborative care component score: 8	Standard care	Duration of programme contact (in months): 6 Outcomes: Response at 6 months Remission at 6 months
Yeung 2016 RCT US	N=190 Baseline severity: More severe Mean age (years): 50 Sex (% female): 63 Ethnicity (% BME): 100	Simple collaborative care Collaborative care component score: 8	Enhanced standard care	Duration of programme contact (in months): 6 Outcomes: Response at 6 months Remission at 6 months

Study

Population

Intervention

Comparison

Comments

Aragones 2012

RCT

Spain

N=360

Baseline severity: More severe

Mean age (years): 47.6

Sex (% female): 79

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 9

Standard care

Duration of programme contact (in months): NR

Outcomes:

Depression symptomatology at 6 months
Depression symptomatology at 12 months
Response at 6 months
Response at 12 months
Remission at 6 months
Remission at 12 months
Antidepressant use at 6 months
Antidepressant use at 12 months
Discontinuation at 6 months
Discontinuation at 12 months

Araya 2003

RCT

Chile

N=240

Baseline severity: More severe

Mean age (years): 42.6

Sex (% female): 100

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 7

Standard care

Duration of programme contact (in months): 3

Outcomes:

Response at 6 months
Remission at 6 months
Antidepressant use at 6 months
Discontinuation at 6 months

Berghofer 2012

RCT

Germany

N=63

Baseline severity: More severe

Mean age (years): 49.7

Sex (% female): 73

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 10

Standard care

Duration of programme contact (in months): 6

Outcomes:

Response at 6 months
Response at 12 months

Bjorkelund 2018

RCT

Sweden

N=385

Baseline severity: Less severe

Mean age (years): 41.2

Sex (% female): 71

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 9

Standard care

Duration of programme contact (in months): 3

Outcomes:

Remission at 6 months
Antidepressant use at 6 months
Discontinuation at 6 months

Bosanquet 2017

RCT

N=485

Baseline severity: Less severe

Mean age (years): 72.2

Sex (% female): 62

Ethnicity (% BME): 2

Simple collaborative care

Collaborative care component score: 8

Enhanced standard care

Duration of programme contact (in months): 2

Outcomes:

Depression symptomatology at 12 months
Antidepressant use at 12 months
Discontinuation at 12 months

Bruce 2004

RCT

N=598

Baseline severity: More severe

Mean age (years): NR (>60)

Sex (% female): 72

Ethnicity (% BME): 28

Simple collaborative care

Collaborative care component score: 11.5

Enhanced standard care

Duration of programme contact (in months): 12

Outcomes:

Depression symptomatology at 12 months
Response at 12 months
Remission at 12 months
Antidepressant use at 12 months
Discontinuation at 12 months

Buszewicz 2016

RCT

N=558

Baseline severity: More severe

Mean age (years): 48.4

Sex (% female): 75

Ethnicity (% BME): 12

Simple collaborative care

Collaborative care component score: 11

Standard care

Duration of programme contact (in months): 24

Outcomes:

Depression symptomatology at 6 months
Depression symptomatology at 12 months
Discontinuation at 6 months
Discontinuation at 12 months

Capoccia 2004

RCT

N=74

Baseline severity: NR

Mean age (years): 38.7

Sex (% female): 77

Ethnicity (% BME): 22

Simple collaborative care

Collaborative care component score: 8

Standard care

Duration of programme contact (in months): 12

Outcomes:

Antidepressant use at 12 months
Discontinuation at 12 months

Chen 2015

RCT

China

N=326

Baseline severity: More severe

Mean age (years): NR (>60)

Sex (% female): 63

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 12

Enhanced standard care

Duration of programme contact (in months): 4

Outcomes:

Depression symptomatology at 6 months
Depression symptomatology at 12 months
Response at 6 months
Response at 12 months
Remission at 6 months
Remission at 12 months
Discontinuation at 6 months
Discontinuation at 12 months

Curth 2020

RCT

Denmark

N=325

Baseline severity: Less severe

Mean age (years): 39

Sex (% female): 67

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 11

Standard care

Duration of programme contact (in months): 4

Outcomes:

Depression symptomatology at 6 months
Discontinuation at 6 months

Dobscha 2006

RCT

N=375

Baseline severity: Less severe

Mean age (years): 56.8

Sex (% female): 7

Ethnicity (% BME): 3

Simple collaborative care

Collaborative care component score: 9

Enhanced standard care

Duration of programme contact (in months): 12

Outcomes:

Antidepressant use at 12 months
Discontinuation at 12 months

Ell 2007

RCT

N=311

Baseline severity: NR

Mean age (years): NR (>60)

Sex (% female): 72

Ethnicity (% BME): 27

Simple collaborative care

Collaborative care component score: 10.5

Enhanced standard care

Duration of programme contact (in months): 12

Outcomes:

Response at 12 months
Remission at 12 months
Antidepressant use at 12 months
Discontinuation at 12 months

Finley 2003

RCT

N=125

Baseline severity: NR

Mean age (years): 54.3

Sex (% female): 85

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 6.5

Standard care

Duration of programme contact (in months): 6

Outcomes:

Antidepressant use at 6 months
Discontinuation at 6 months

Fortney 2007

RCT

N=395

Baseline severity: More severe

Mean age (years): 59.2

Sex (% female): 8

Ethnicity (% BME): 25

Complex collaborative care

Collaborative care component score: 13

Enhanced standard care

Duration of programme contact (in months): 12

Outcomes:

Antidepressant use at 12 months
Discontinuation at 12 months

Gensichen 2009

RCT

Germany

N=626

Baseline severity: More severe

Mean age (years): 51.1

Sex (% female): 76

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 7

Standard care

Duration of programme contact (in months): 12

Outcomes:

Depression symptomatology at 12 months
Response at 12 months
Remission at 12 months
Antidepressant use at 12 months
Discontinuation at 12 months

Gilbody 2017/Lewis 2017

RCT

N=705

Baseline severity: Less severe

Mean age (years): 77.3

Sex (% female): 58

Ethnicity (% BME): 1

Simple collaborative care

Collaborative care component score: 10

Standard care

Duration of programme contact (in months): 2

Outcomes:

Depression symptomatology at 12 months
Antidepressant use at 12 months
Discontinuation at 12 months

Harter 2018

RCT

Germany

N=779

Baseline severity: Less severe

Mean age (years): 42.9

Sex (% female): 73

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 11

Standard care

Duration of programme contact (in months): NR

Outcomes:

Depression symptomatology at 6 months
Depression symptomatology at 12 months
Response at 12 months
Remission at 12 months
Discontinuation at 6 months
Discontinuation at 12 months

Holzel 2018

RCT

Germany

N=248

Baseline severity: Less severe

Mean age (years): 71.4

Sex (% female): 77

Ethnicity (% BME): NR

Complex collaborative care

Collaborative care component score: 14

Standard care

Duration of programme contact (in months): 12

Outcomes:

Depression symptomatology at 12 months
Response at 12 months
Remission at 12 months

Huang 2018

RCT

China

N=280

Baseline severity: More severe

Mean age (years): 47.4

Sex (% female): 85

Ethnicity (% BME): 100

Simple collaborative care

Collaborative care component score: 10

Standard care

Duration of programme contact (in months): 6

Outcomes:

Depression symptomatology at 6 months
Discontinuation at 6 months

Huijbregts 2013

RCT

Netherlands

N=150

Baseline severity: Less severe

Mean age (years): 48.7

Sex (% female): 73

Ethnicity (% BME): 29

Complex collaborative care

Collaborative care component score: 13

Standard care

Duration of programme contact (in months): 12

Outcomes:

Response at 6 months
Response at 12 months
Remission at 6 months
Remission at 12 months
Discontinuation at 6 months
Discontinuation at 12 months

Jarjoura 2004

RCT

N=61

Baseline severity: More severe

Mean age (years): 45.5

Sex (% female): 69

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 6

Enhanced standard care

Duration of programme contact (in months): NR

Outcomes:

Antidepressant use at 12 months

Jeong 2013

RCT

Korea

N=57

Baseline severity: More severe

Mean age (years): NR (>60)

Sex (% female): 58

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 7

Standard care

Duration of programme contact (in months): 6

Outcomes:

Remission at 6 months
Antidepressant use at 6 months
Discontinuation at 6 months

Katon 1999

RCT

N=228

Baseline severity: NR

Mean age (years): 47

Sex (% female): 75

Ethnicity (% BME): 20

Simple collaborative care

Collaborative care component score: 6

Standard care

Duration of programme contact (in months): 3

Outcomes:

Remission at 6 months
Antidepressant use at 6 months

Katzelnick 2000

RCT

N=407

Baseline severity: More severe

Mean age (years): 45.5

Sex (% female): 77

Ethnicity (% BME): 21

Simple collaborative care

Collaborative care component score: 9

Standard care

Duration of programme contact (in months): 7

Outcomes:

Response at 12 months
Remission at 12 months
Discontinuation at 12 months

Landis 2007

RCT

N=45

Baseline severity: More severe

Mean age (years): 39.7

Sex (% female): 96

Ethnicity (% BME): 28

Simple collaborative care

Collaborative care component score: 9

Enhanced standard care

Duration of programme contact (in months): 6

Outcome:

Depression symptomatology at 6 months

Ludman 2007

RCT

N=52

Baseline severity: NR

Mean age (years): 50.3

Sex (% female): 69

Ethnicity (% BME): 13

Simple collaborative care

Collaborative care component score: 9

Standard care

Duration of programme contact (in months): NR

Outcomes:

Remission at 12 months
Antidepressant use at 12 months
Discontinuation at 12 months

Morris 2016

RCT

N=187

Baseline severity: More severe

Mean age (years): 46.5

Sex (% female): 61

Ethnicity (% BME): NR

Complex collaborative care

Collaborative care component score: 14

Standard care

Duration of programme contact (in months): 12

Outcomes:

Depression symptomatology at 12 months
Response at 12 months
Remission at 12 months
Discontinuation at 12 months

Ng 2020

RCT

Singapore

N=274

Baseline severity: Less severe

Mean age (years): 73.5

Sex (% female): 56

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 9

Standard care

Duration of programme contact (in months): 6

Outcomes:

Depression symptomatology at 6 months
Depression symptomatology at 12 months
Response at 6 months
Response at 12 months
Remission at 6 months
Remission at 12 months
Discontinuation at 6 months
Discontinuation at 12 months

Oladeji 2015

RCT

Nigeria

N=234

Baseline severity: Less severe

Mean age (years): 43.2

Sex (% female): 80

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 12

Enhanced standard care

Duration of programme contact (in months): 6

Outcomes:

Depression symptomatology at 6 months
Discontinuation at 6 months

Richards 2013/2016

RCT

N=581

Baseline severity: More severe

Mean age (years): 44.8

Sex (% female): 72

Ethnicity (% BME): 15

Simple collaborative care

Collaborative care component score: 12

Standard care

Duration of programme contact (in months): 3

Outcomes:

Depression symptomatology at 12 months
Response at 12 months
Remission at 12 months
Antidepressant use at 12 months
Discontinuation at 12 months

Simon 2004 (CM)

RCT

N=402

Baseline severity: Less severe

Mean age (years): 44.5

Sex (% female): 75

Ethnicity (% BME): 20

Simple collaborative care

Collaborative care component score: 9

Standard care

Duration of programme contact (in months): 5

Outcomes:

Antidepressant use at 6 months
Discontinuation at 6 months

Simon 2004 (CM + psych)

RCT

N=393

Baseline severity: Less severe

Mean age (years): 44.4

Sex (% female): 76

Ethnicity (% BME): 23

Complex collaborative care

Collaborative care component score:13

Standard care

Duration of programme contact (in months): 5

Outcomes:

Antidepressant use at 6 months
Discontinuation at 6 months

Simon 2006

RCT

N=207

Baseline severity: Less severe

Mean age (years): 43

Sex (% female): 65

Ethnicity (% BME): 11

Simple collaborative care

Collaborative care component score: 9

Standard care

Duration of programme contact (in months): 3

Outcomes:

Antidepressant use at 6 months
Discontinuation at 6 months

Smit 2006

RCT

Netherlands

N=267

Baseline severity: Less severe

Mean age (years): 42.8

Sex (% female): 64

Ethnicity (% BME): NR

Simple collaborative care

Collaborative care component score: 9.5

Standard care

Duration of programme contact (in months): 6

Outcomes:

Remission at 6 months
Antidepressant use at 6 months
Discontinuation at 6 months

Swindle 2003

RCT

N=268

Baseline severity: Less severe

Mean age (years): 56.3

Sex (% female): 3

Ethnicity (% BME): 15

Simple collaborative care

Collaborative care component score: 8

Enhanced standard care

Duration of programme contact (in months): 2

Outcomes:

Depression symptomatology at 12 months
Discontinuation at 12 months

Unutzer 2002/Arean 2005

RCT

N=1901

Baseline severity: NR

Mean age (years): 71.2

Sex (% female): 65

Ethnicity (% BME): 23

Complex collaborative care

Collaborative care component score: 14.5

Standard care

Duration of programme contact (in months): 12

Outcomes:

Antidepressant use at 6 months
Antidepressant use at 12 months
Discontinuation at 6 months
Discontinuation at 12 months

Wells 2000

RCT

N=1356

Baseline severity: NR

Mean age (years): 43.7

Sex (% female): 71

Ethnicity (% BME): 43

Simple collaborative care

Collaborative care component score: 8.5

Standard care

Duration of programme contact (in months): 12

Outcomes:

Remission at 6 months
Remission at 12 months
Discontinuation at 6 months
Discontinuation at 12 months

Yeung 2010

RCT

N=100

Baseline severity: More severe

Mean age (years): 49

Sex (% female): 68

Ethnicity (% BME): 100

Simple collaborative care

Collaborative care component score: 8

Standard care

Duration of programme contact (in months): 6

Outcomes:

Response at 6 months
Remission at 6 months

Yeung 2016

RCT

N=190

Baseline severity: More severe

Mean age (years): 50

Sex (% female): 63

Ethnicity (% BME): 100

Simple collaborative care

Collaborative care component score: 8

Enhanced standard care

Duration of programme contact (in months): 6

Outcomes:

Response at 6 months
Remission at 6 months

: BME: black minority ethnic; N: number; NR: not reported; RCT: randomised controlled trial

From: Service delivery Models and settings for delivery of services

Cover of Service delivery Models and settings for delivery of services

Service delivery Models and settings for delivery of services: Depression in adults: Evidence review A.

NICE Guideline, No. 222.

London: National Institute for Health and Care Excellence (NICE); 2022 Jun.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.