Table 10, Summary of included studies. Comparison 9. Augmenting with art therapy versus attention-placebo - Further-line treatment

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Study	Population	Intervention	Comparison	Details of inadequate response/treatment resistance	Comments
Nan 2017 RCT China	N=106 Mean age (years): 45.1 Gender (% female): 89 Ethnicity (% BME): NR Baseline severity: BDI-II 30.59 (more severe)	Clay art therapy + any antidepressant Intensity: 6x 2.5-hour sessions	Attention-placebo (non-directive visual art control group) + any antidepressant Intensity: 6x 2.5-hour sessions	Inadequate response (BDI-II≥10) after taking 1 or more antidepressants at an adequate dosage for at least 4 weeks	Treatment length (weeks): 6 Outcomes: Depression symptomatology endpoint Depression symptomatology change score Discontinuation due to any reason

Study

Population

Intervention

Comparison

Details of inadequate response/treatment resistance

Comments

RCT

China

N=106

Mean age (years): 45.1

Gender (% female): 89

Ethnicity (% BME): NR

Baseline severity: BDI-II 30.59 (more severe)

Clay art therapy + any antidepressant

Intensity: 6x 2.5-hour sessions

Attention-placebo (non-directive visual art control group) + any antidepressant

Intensity: 6x 2.5-hour sessions

Inadequate response (BDI-II≥10) after taking 1 or more antidepressants at an adequate dosage for at least 4 weeks

Treatment length (weeks): 6

Outcomes:

: BDI-II: Beck depression inventory; BME: black and minority ethnic; NR: not reported; RCT: randomised controlled trial

Further-line treatment: Depression in adults: Evidence review D.

NICE Guideline, No. 222.

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