Table 11Summary of included studies. Comparison 10. Augmenting with eye movement desensitization reprocessing (EMDR) versus augmenting with cognitive behavioural therapy

StudyPopulationInterventionComparisonDetails of inadequate response/treatment resistanceComments

Ostacoli 2018

RCT

Italy & Spain

N=82

Mean age (years): 47.9

Gender (% female): 84

Ethnicity (% BME): NR

Baseline severity: NR (less severe)

Eye Movement Desensitization Reprocessing (EMDR), following the DeprEnd protocol (Hofmann et al. 2016) + any antidepressant

Intensity: 12-18 sessions

CBT individual (Beck, 1979) + any antidepressant

Intensity: 12-18 sessions

Inadequate response (BDI-II≥10) after taking 1 or more antidepressants at an adequate dosage for at least 4 weeks

Treatment length (weeks): 13-26

Outcomes:

  • Depression symptomatology endpoint
  • Remission at:
    • Endpoint
    • 6-month follow-up
  • Discontinuation due to any reason
  • Global functioning at:
    • Endpoint
    • 6-month follow-up

BDI-II: Beck depression index; BME: black and minority ethnic; CBT: cognitive behavioural therapy; NR: not reported; RCT: randomised controlled trial

From: Further-line treatment

Cover of Further-line treatment
Further-line treatment: Depression in adults: Evidence review D.
NICE Guideline, No. 222.
Copyright © NICE 2022.

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