Table 22Summary of included studies. Comparison 21. Switching to TCA versus SSRI

StudyPopulationInterventionComparisonDetails of inadequate response/treatment resistanceComments

Souery 2011a

RCT

Austria, Belgium, France & Israel

N=189

Mean age (years): 51.4

Gender (% female): 72

Ethnicity (% BME): 5

Baseline severity: MADRS 31.5 (more severe)

Desipramine minimum dose 150mg/day (mean final dose 169.61mg/day)Citalopram minimum dose 40mg/day (mean final dose 43.06mg/day)Inadequate response to treatment with at least 1 antidepressant (except citalopram and desipramine) given at an adequate dose for at least 4 weeks

Treatment length (weeks): 4

Outcomes:

  • Depression symptomatology endpoint
  • Remission
  • Response
  • Discontinuation due to any reason

BME: black and minority ethnic; MADRS: Montgomery-Asberg depression rating scale; RCT: randomised controlled trial; SSRI: selective serotonin reuptake inhibitor; TCA: tricyclic antidepressant

From: Further-line treatment

Cover of Further-line treatment
Further-line treatment: Depression in adults: Evidence review D.
NICE Guideline, No. 222.
Copyright © NICE 2022.

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