Table 3Summary of included studies. Comparison 2. Augmenting with cognitive and cognitive behavioural therapies versus augmenting with counselling

StudyPopulationInterventionComparisonDetails of inadequate response/treatment resistanceComments

Kocsis 2009/Klein 2011

RCT

US

N=395

Mean age (years): 45.8

Gender (% female): 57

Ethnicity (% BME): 10

Baseline severity: HAMD 19.48 (more severe)

Cognitive behavioral analysis system of psychotherapy (CBASP) + any antidepressant (algorithm-based)

Intensity: 16-20 sessions

Brief Supportive Psychotherapy + any antidepressant (algorithm-based)Inadequate response (≥60% reduction in HAMD score, a HAMD total score<8, and no longer meeting DSM-IV criteria for MDD for 2 consecutive visits during weeks 6-12) to 12 weeks of antidepressant medication according to a pharmacotherapy algorithm

Treatment length (weeks): 12

Outcomes:

  • Depression symptomatology endpoint
  • Remission
  • Discontinuation due to any reason
  • Discontinuation due to side effects
  • Functional impairment endpoint

BME: black and minority ethnic; DSM: diagnostic statistical manual; HAMD: Hamilton depression scale; MDD: major depressive disorder; RCT: randomised controlled trial

From: Further-line treatment

Cover of Further-line treatment
Further-line treatment: Depression in adults: Evidence review D.
NICE Guideline, No. 222.
Copyright © NICE 2022.

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