From: Further-line treatment
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Study | Population | Intervention | Comparison | Details of inadequate response/treatment resistance | Comments |
---|---|---|---|---|---|
RCT Canada |
N=64 Mean age (years): 45.2 Gender (% female): 72 Ethnicity (% BME): NR Baseline severity: NR (unclear severity) |
IPT group (Re-ChORD) + any antidepressant Intensity: 16x 90-min sessions | Any antidepressant | TRD: Mean 2.95 (SD=1.1) failed medication trials |
Treatment length (weeks): 16 Outcomes:
|
RCT US |
N=124 Mean age (years): 72.3 Gender (% female): 68 Ethnicity (% BME): 8 Baseline severity: HAMD 12.5 (less severe) |
IPT individual + escitalopram (dose increase; 10-20mg/day) Intensity: IPT 16x 60-75 min sessions | Escitalopram (dose increase; 10-20mg/day) | Inadequate (partial) response (HAMD score=11-14) to 6 weeks prospective open-label treatment with escitalopram |
Treatment length (weeks): 16 Outcomes:
|
RCT Germany |
N=130 Mean age (years): 41.9 Gender (% female): 65 Ethnicity (% BME): NR Baseline severity: HAMD 23.53 (more severe) |
IPT individual & group (modified for an inpatient setting) + SSRI/TCA (sertraline 50-250mg/day or amitriptyline 75-360mg/day) Intensity: 15x 50-min individual sessions | SSRI/TCA (sertraline 50-250mg/day or amitriptyline 75-360mg/day) | Inadequate response: met inclusion criteria despite 83% having received outpatient treatment before admission |
Treatment length (weeks): 5 Outcomes:
|
RCT Brazil |
N=40 Mean age (years): 49.2 Gender (% female): 85 Ethnicity (% BME): NR Baseline severity: HAMD 19 (more severe) |
IPT individual + any antidepressant Intensity: 16x 40-min weekly sessions | Any antidepressant | Inadequate response to 1 trial of antidepressant medication in adequate dose (defined as the equivalent of at least 75mg of amitriptyline) and duration (at least 4 weeks) |
Treatment length (weeks): 19 Outcomes:
|
BME: black and minority ethnic; HAMD: Hamilton depression scale; IPT: interpersonal therapy; NR: not reported; RCT: randomised controlled trial; SD: standard deviation; SSRI: selective serotonin reuptake inhibitors; TCA: tricyclic antidepressants; TRD: treatment-resistant depression
From: Further-line treatment
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.